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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2001.12
- 수록면
- 309 - 316 (8page)
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초록· 키워드
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Male Sprague Dawley rats were exposed to 0, 0.04, 0.2, and 0.8% Pb acetate in drinking water for 13 weeks and fed a commercial diet. Dose-related adverse effects observed at the end of the Pb acetate exposure in the drinking water were as follows: decrease in body weight gain, decrease in hemoglobin, hematocrit(HCT), mean corpuscular valume (MCV) and mean corpuscular hemoglobin (MCH), increase in serum glucose, decrease in serum testosterone, increase in lead accumulation and δ-ALA telease in urine, and decrease in δ-ALAD activities of all tissues examined, increase in relative organ weights (kidney, spleen, testis), and changes in testicular DNA content and histopathology (intranuclear inclusion body in kidney proximal tubule cell). Taken together, repeated exposure of lead acetate incuced toxicities in hematopoletic system, especially testis and kidney.
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