Initial Risk Assessment of Acetanilide in OECD High Production Volume Chemical Program

Hye-Youn Park; Yoonho Choi; Sanghwan Song; Min-Jeoung Kwon; Hyun Ju Koo; Seong-Hwan Jeon; Jin-Gyun Na; Kwangsik Park

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자료유형: 학술저널

저자정보: Hye-Youn Park Yoonho Choi Sanghwan Song Min-Jeoung Kwon Hyun Ju Koo Seong-Hwan Jeon Jin-Gyun Na Kwangsik Park

저널정보: 한국독성학회 Toxicological Research Journal of Toxicology and Public Health Vol.18 No.1

발행연도: 2002.3

수록면: 13 - 22 (10page)

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In Korea, 2,320 tonnes of acetanilide were mostly used as intermediates for synthesis in pharmaceuticals or additives in synthesizing hydrogen peroxide, varnishes, polymers and rubber. Only small amount of 120 kg were used as a stabilizer for hydrogen peroxide solution for hair colouring agents in 1998. Readily available environmental or human exposure data do not exist in Korea at the present time. However, potential human exposures from drinking water, food, ambient water and in work places are expected to be negligible because this chemical is produced in the closed system in only one company in Korea and the processing factory is equipped with local ventilation and air filtering system. Acetanilide could be distributed mainly to water based on EQC model. This substance is readily biodegradable and its bioaccumulation is low. Acute toxicity of acetanilide is low since the LD_(50) of oral exposure in rats is 1,959 mg/kg bw. This chemical is not irritating to skin, but slightly irritating to the eyes of rabbits. From repeated dose toxicity, the adverse effects in rats were red pulp hyperplasia of spleen, bone marrow hyperplasia of femur and decreased hemoglobin, hematocrit and mean corpuscular hemoglobin concentration. The LOAEL for repeated dose toxicity in rats was 22 mg/kg/day for both sexes. Acetanilide is not considered to be genotoxic. In a reproductive/developmental toxicity study, no treatment-related changes in precoital time and rate of copulation, impregnation, pregnancy were shown in all treated gruops. The NOAELs for reproduction and developmental toxicity (off-spring toxicity) are considered to be 200 mg/kg bw/day and 67 mg/kg bw/day, respectively. Ecotoxicity data has been generated in a limited number of aquatic species of algae (72hr-E_bC_(50); 13.5 mg/l), daphnid (48hr-EC_(50); > 100 mg/l) and fish(Oryzias latipes, 96hr-LC_(50); 100 mg/l). From the acute toxicity values, the predicted no effect concentration (PNEC) of 0.135 mg/l was derived using an assessment factor of 100. On the basis of these data, acetanilide was suggested as currently of low priority for further post-SIDS work in OECD.

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김민선, 김우일, 신선경, 강영렬, 조윤아, 정성경, 김나, 연진모, 이지영. 재활용 플라스틱 제품 중 고무대야의 중금속 노출량 평가. 분석과학. 2013

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