지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2004.6
- 수록면
- 51 - 66 (16page)
이용수
초록· 키워드
오류제보하기
Retinoids, better known as vitamin A, have been reported to inhibit the growth of several breast cancer cell lines in culture and to reduce breast tumor growth in animal models. Furthermore, retinoids can augment the action of other breast cancer cell growth inhibitors both in vitro and in vivo. Clinically, interest has increased in the potential use of retinoids for the prevention and treatment of human breast cancer. We have examine the effect of all-trans retinoic acid(tRA) and 9-cis retinoic acid(9-cis RA) on human breast cancer cell(MCF-10A, T47-D, MCF-7) proliferation using MTT assay and cell cycle analysis(FACS), Overexpression of cyclin D1 protein is observed in the majority of breast cancers, suggesting that dysregulated expression of cyclin D1 might be a critical event in breast cancer carcinogenesis. We investigated whether tRA and 9-cis RA might affect expression of cyclin D1 on human breast cancer cells(MCF-10A, T47-D, MCF-7) using RT-PCR and western bolt. In MCF-IOA cells, either tRA or 9-cis RA treatment did not affect the cell proliferation. In T47-D cells and MCF-7 cells, either tRA or 9-cis RA treatment showed the inhibition of the cell proliferation over control cells and also inhibit the estrogen stimulated cell proliferation when it was given together with estrogen. The effect of retinoids was dose-and time-dependent. T47-D cells treated with 1.0 μM tRA undergo G0/G1-phase arrest by Day 5. MCF-7 cells treated with 1.0 μM tRA undergo S-phase arrest by Day 5. All-trans retinoic acid(tRA) and 9-cis retinoic acid(9-cis RA) inhibited the cyclin D1 mRNA and protein expression levels of human MCF-7 and T47-D breast carcinoma cells in vitro. The data indicate that retinoids can reduce cyclin D1 expression levels in a variety of breast cell lines in vitro and result in inhibition of cell proliferation. tRA-mediated growth inhibition and cyclin D1 expression inhibition is more potent than 9-cis RA mediated that. tRA-mediated inhibition effect is more Potent on T47-D cells than on MCF-7 cells. Our data suggest that retinoids activity is different according to property of cell lines. Future chemoprevention of breast cancer studies using retinoids will be necessary to determine the mechanism of the retinoids-mediated growth inhibition.
목차
Abstract
서론
재료 및 방법
결과
고찰
결론
참고문헌
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Effect of all trans retinoic acid and 9-cis-retinoic acid on human breast cancer MCF-7 cell Proliferation.
대한약학회 학술대회
2002 .01
-
인체 유방암 세포에서 과다발현 시킨 Cyclin D2의 영향에 대한 연구
한국환경성돌연변이·발암원학회지
2004 .03
-
Apoptotic Effects of 6-Gingerol in Human Breast Cancer Cells
International Journal of Oral Biology
2015 .01
-
Effects of Metformin on Cell Kinetic Parameters of MCF-7 Breast Cancer Cells in Vitro
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
참옻 추출물의 MCF-7 인체 유방암 세포에서 증식 억제효과
대한한의학방제학회지
2016 .01
-
Glehnia littoralis Root Extract Induces G0/G1 Phase Cell Cycle Arrest in the MCF-7 Human Breast Cancer Cell Line
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
Cadmium Induces Cell Cycle Arrest and Change in Expression of Cell Cycle Related Proteins in Breast Cancer Cell Lines
Toxicological Research
2005 .03
-
Lycopene Inhibits Proliferation, Invasion and Migration of Human Breast Cancer Cells
Biomolecules & Therapeutics(구 응용약물학회지)
2010 .01
-
Insulin Promotes Proliferation and Migration of Breast Cancer Cells through the Extracellular Regulated Kinase Pathway
Asian Pacific journal of cancer prevention : APJCP
2014 .01
-
Panduratin A Inhibits Cell Proliferation by Inducing G0/G1 Phase Cell Cycle Arrest and Induces Apoptosis in Breast Cancer Cells
Biomolecules & Therapeutics(구 응용약물학회지)
2018 .01
-
Effects of Rapamycin on Cell Apoptosis in MCF-7 Human Breast Cancer Cells
Asian Pacific journal of cancer prevention : APJCP
2014 .01
-
A Novel All-trans Retinoid Acid Derivative Induces Apoptosis in MDA-MB-231 Breast Cancer Cells
Asian Pacific journal of cancer prevention : APJCP
2014 .01
-
Transforming Growth Factor-${\beta}$ (TGF-${\beta}$) Induces Invasion and Migration of Ras- Transformed MCF10A Human Breast Epithelial Cells
대한약학회 학술대회
2002 .01
-
Regulation of the E-cadherin Expression on Human Breast Cancer Cell Line(MCF-7) by Anticancer Agents
한국실험동물학회 학술발표대회 논문집
1999 .05
-
Treatment with octylphenol can lead to stimulate breast cancer cell growth via the alterations of cyclin D1 and p21 genes in human breast cancer cells through an estrogen receptor-mediated signaling pathway in breast cancer xenografted mice
한국실험동물학회 학술발표대회 논문집
2013 .08
-
Comparative Evaluation of Silibinin Effects on Cell Cycling and Apoptosis in Human Breast Cancer MCF-7 and T47D Cell Lines
Asian Pacific journal of cancer prevention : APJCP
2016 .01
-
知母 추출물이 MCF-7 세포의 생존율에 미치는 영향
대한한방내과학회지
2007 .01
-
Cancer stem cells in breast cancer
대한외과학회 학술대회 초록집
2009 .11
-
Regulation of CYP1B1 Promotor Activity In MCF-7 Human Breast Cancer Cells
환경독성보건학회 심포지엄 및 학술대회
2005 .05
이 논문의 저자 정보
이 논문과 함께 이용한 논문
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2009-476-017705503