지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2005.6
- 수록면
- 129 - 134 (6page)
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초록· 키워드
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Styrene is a commercially important chemical used mainly in the production of plastics. A toxic effect exerted by styrene exposure may cause infertility, congenital anomalies or death in offspring. Treatment with styrene for 0, 50, 100, and 500 ㎎/㎏ for 5 days in Sprague-Dawley rats significantly decreased sperm motilities and sperm counts while sperm abnormalities were significantly increased. To determine the relationship between changes in sperm motilities and roles of reactive oxygen species (ROS), we determined the effect of styrene on ROS production and mRNA expression of antioxidant enzymes in rats. ROS production was enhanced by styrene treatment in a dose-dependent manner. The mRNA expression of catalase and superoxide dismutase (SOD) 2 was strongly suppressed by styrene treatment although SOD1 or glutathione peroxidase (GPX) 4 expressions were not significantly changed. Taken together, these results indicate that styrene may cause toxic effect in rat sperm cells by enhancing oxidative stresses.
목차
ABSTRACT
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
ACKNOWLEDGEMENTS
REFERENCES
참고문헌 (19)
참고문헌 신청
, 1989183-197 , Generation of reactive oxygen species
, 1989 , Role of glutathione peroxidase in protecting mammalian spermatozoa from loss of motility caused by spontaneous lipid peroxidation : 77 ~ 90
, 1987 , Spontaneous lipid peroxidation and production of hydrogen peroxide and superoxide in human spermatozoa Superoxide dismutase as major enzyme protectant against oxygen toxicity : 338 ~ 348
, 1983 , Potassium-dependent increases in cytosolic pH stimulate metabolism and motility of mammalian sperm : 1327 ~ 1331
, 1998 , Solution structure of reduced monomeric Q133M2 copper 37 : 11780 ~ 11791
, 1989 , Role of glutathione peroxidase in protecting mammalian spermatozoa from loss of motility caused by spontaneous lipid peroxidation : 77 ~ 90
, 1987 , Spontaneous lipid peroxidation and production of hydrogen peroxide and superoxide in human spermatozoa Superoxide dismutase as major enzyme protectant against oxygen toxicity : 338 ~ 348
, 1983 , Potassium-dependent increases in cytosolic pH stimulate metabolism and motility of mammalian sperm : 1327 ~ 1331
, 1998 , Solution structure of reduced monomeric Q133M2 copper 37 : 11780 ~ 11791
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1991 .01
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UCI(KEPA) : I410-ECN-0101-2009-513-017791541