임신중인 생쥐에 Bisphenol A 투여가 모체의 생식독성과 태아의 성비에 미치는 영향

박동헌; 장현용; 김정익; 정희태; 박춘근; 양부근

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자료유형: 학술저널

저자정보: 박동헌 장현용 김정익 정희태 박춘근 양부근

저널정보: 한국독성학회 Toxicological Research Journal of Toxicology and Public Health Vol.21 No.2

발행연도: 2005.6

수록면: 161 - 165 (5page)

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이 논문의 연구 히스토리 (2)

2005

임신중인 생쥐에 Bisphenol A 투여가 모체의 생식독성과 태아의 성비에 미치는 영향

박동헌 , 장현용 , 김정익 외 3명 Toxicological Research 2005.06 학술저널

2001

Bisphenol A의 투여가 생쥐의 번식효율에 미치는 영향

박동헌 , 최영진 , 정희태 외 3명 한국동물번식학회 학술대회 2001.01 학술대회자료

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Bisphenol A (BPA), a environmental endocrine disruptor, is considered to bind to estrogen receptors and to regulate the expressions of estrogen responsive genes. This study was to evaluate the effect of BPA administration on body weight, sex ratio and litter size on 18 days in prenatal periods, the effect of reproductive organ weight and blood hematological values on 24 days postpartum in pregnant mice. The female mice was administrated to low doses of BPA (0, 0.05, 0.5 and 5.0 ㎎/㎏ B.W.) by intraperitoneal injection in gestation days 0~15 with 5 times at 3 days interval. The maternal body weight, litter size and sex ratios were similar to in all experimental groups, but body weights of male and female offspring was significantly lower in 5.0 ㎎ BPA group when compared to any other groups (P<0.05). No treatment-related effects on body weight, ovary weight and blood hematological values were observed in dams on 24 days after delivery. The uterine weight in 5.0 ㎎ BPA group was slightly higher than those of any other groups, but not significantly difference. The histological evaluation of ovary in dam mice on 24 days after dilivery was not difference in all experimental groups, but the endometriosis of uterus in dam mice were significantly increased in 0.5 ㎎ BPA group when compared to control group. These results indicates that low concentration of BPA should not be considered as a selective reproductive toxicant.

참고문헌 (16)

참고문헌 신청

, 1999 , Lack of effects for low dose levels of bisphenol A and diethylstilbestrol on the prostate gland of CF1 mice exposed in utero 30 : 156 ~ 166

, 1999 , Tissue compartment-specific estrogen receptor-a participation in the mouse uterine epithelial secretory response 140 (logy) : 484 ~ 491

, 1999 , Normal reproductive organ develoment in Wistar rats exposed to bisphenol A in the drinking water : 130 ~ 139

, 1987 , Degradation of bisphenol A in the natural waters 16 : 1501 ~ 1507

, 1992 , RP-HPLC-TSP-MS of epoxy resins bisphenol A diglycidylether type : 11 ~ 16

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