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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2005.9
- 수록면
- 187 - 193 (7page)
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The rodent Hershberger assay is considered as a potential short term in vivo screening method for the detection of androgenic or anti-androgenic compounds. The objective of this study was to evaluate the anti-androgenic activities of di (2-ethylhexyl) phthalate (DEHP), di (n-butyl) phthalate (DBP), and butylbenzyl phthalate (BBP). A 10-day Hershberger assay was performed using immature Sprague-Dawley male rats castrated at 6 weeks of age. Testosterone propionate (TP, 0.4 ㎎/㎏/day) was administered s.c. to castrated male rats and followed by flutamide (1, 5, 10, or 20 ㎎/㎏/day) treatment for 10 days by oral gavage. Similarly, DEHP, DBP, or BBP were also administered by oral gavage at 250, 500, or 1000 ㎎/㎏/day after TP (0.4 ㎎/㎏/day) administration. As expected, flutamide significantly inhibited the TP-induced re-growth of seminal vesicles, ventral prostate, and Levator ani plus bulbocavernosus muscles (LABC) at 1 ㎎/㎏/day and above, and Cowper’s glands and glans penis at 5 ㎎/㎏/day and above. DEHP significantly (p < 0.05) decreased the seminal vesicles, ventral prostate, LABC and Cowper’s glands weights at 1000 ㎎/㎏/day. BBP at 1000 ㎎/㎏/day significantly inhibited TP-induced re-growth of the LABC in the immature castrated male rats, whereas ventral prostate, seminal vesicles, and Cowper’s glands weights were unaffected. In contrast to DEHP, DBP did not affect accessory sex organ weights at any concentration. Body weights, combined adrenal glands, and kidney weights were not affected, but liver weights were significantly increased at high dosages in the DEHP, DBP, and BBP treatment groups. Our observations strongly suggest that DEHP acts as an androgen antagonist at the high dose (i.e., 1000 ㎎/㎏/day).
목차
ABSTRACT
INTRODUCTION
MATERIALS AND METHOD
RESULTS
DISCUSSION
ACKNOWLEDGEMENT
REFERENCES
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UCI(KEPA) : I410-ECN-0101-2009-513-018052369