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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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The effects of formalin on mixed function oxygenase (MFO) system and stress-response were investigated in olive flounder (Paralichthys olivaceus). Olive flounder was exposed to formalin at the concentration of 300 ppm for 1, 2, 4 and 16 h. Levels of stress-response enzymes together with total protein, glucose and osmolality were quantitatively determined in blood, and the activities of phase Ⅰ (cytochrome P450, ethoxyresorufin deethylase) and phase Ⅱ (glutathione S-transferase) hepatic enzymes were also determined. Since the formalin-exposure for 16 h resulted no significant changes in aspartate aminotransferase and alanine aminotransferase, specific enzymes for liver damage, it was thought that it did not cause hepatic tissue damage at the concentration of 300 ppm. However, hepatic MFO system was induced at 1 to 4 h, and stress response was induced after 16 h of exposure. Moreover, it is considered that the depression of MFO activity after 16 h of exposure may not be adaptation to formalin, but toxic response. These results suggest that low concentration of formalin does not cause hepatic tissue damage of fish, but could induce MFO and stress response.
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Abstract
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재료 및 방법
결과 및 고찰
결론
감사의 글
참고문헌
참고문헌 (27)
참고문헌 신청
[학술지(정기간행물)] - Burke, M. D / 1974 / Ethoxyresorufin: direct fluorimetric assay of a microsomal O-dealkylation which is preferentially inducible by 3-methylcholanthrene / Drug Metab. Dispos 2 : 583 ~ 588
[학술지(정기간행물)] - Fent, K / 1994 / Inhibition of hepatic microsomal monooxygenase system by organotins in vitro in freshwater fish / Aquat. Toxicol 28 : 107 ~ 126
[학술지(정기간행물)] - Fent, K. / 1991 / Effects of tributyltin chloride in vitro on the hepatic microsomal monooxygenase system in the fish Stenotomus chrysops / Aquat. Toxicol 20 : 159 ~ 168
[학술지(정기간행물)] - Fevolden, S. E / 1993 / Disease resistance in Atlantic salmon (Salmo salar) selected for high or low responses to stress / Aquaculture 109 : 215 ~ 224
[학술지(정기간행물)] - Fevolden, S. E. / 1993 / Cortisol and immune characteristics in rainbow trout (Oncorhynchus mykiss) selected for high or low responses to stress / J. Fish Biol 43 : 919 ~ 930
[학술지(정기간행물)] - Fent, K / 1994 / Inhibition of hepatic microsomal monooxygenase system by organotins in vitro in freshwater fish / Aquat. Toxicol 28 : 107 ~ 126
[학술지(정기간행물)] - Fent, K. / 1991 / Effects of tributyltin chloride in vitro on the hepatic microsomal monooxygenase system in the fish Stenotomus chrysops / Aquat. Toxicol 20 : 159 ~ 168
[학술지(정기간행물)] - Fevolden, S. E / 1993 / Disease resistance in Atlantic salmon (Salmo salar) selected for high or low responses to stress / Aquaculture 109 : 215 ~ 224
[학술지(정기간행물)] - Fevolden, S. E. / 1993 / Cortisol and immune characteristics in rainbow trout (Oncorhynchus mykiss) selected for high or low responses to stress / J. Fish Biol 43 : 919 ~ 930
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