개인구독
소속 기관이 없으신 경우, 개인 정기구독을 하시면 저렴하게
논문을 무제한 열람 이용할 수 있어요.
지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2006.6
- 수록면
- 87 - 93 (7page)
이용수
초록· 키워드
오류제보하기
The KFDA (Korea Food & Drug Administration) has performed a collaborative toxicogenomics project since 2003. Its aim is to construct a toxicologenomic database of 12 hepatotoxic compounds from mice livers. Phenylbutazone which is non-steroidal anti-inflammatory drug was assigned. It was administered at low (0.0238 ㎎/㎏) and at high (0.238 ㎎/㎏) dose (5 mice per group) orally to the postnatal 6 weeks ICR mice, then the serum and liver were collected at the indicated time (6, 24 and 72 h) after administration. Serum biochemical markers for liver toxicity were measured and histopathologic studies also were carried out. The gene expression profiling was carried out by using Applied Biosystems 1700 Full Genome Expression Mouse. The 2-way ANOVA was used to find genes that reflected phenylbutazone-induced acute toxicity or dose-dependant changes. By self-organization maps (SOM), we identified groups with unique gene expression patterns, some of them are supposed to be related to phenylbutazone induced toxicity, including lipid metabolism abnormality, oxidative stress, cell death and cytoskeleton destruction.
목차
ABSTRACT
서론
재료 및 방법
결과 및 고찰
감사의 글
참고문헌
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
아세트아미노펜에 의해 간손상이 유발된 랫드의 유전자 발현 분석
Toxicological Research
2006 .12
-
Gene expression profile in liver of streptozotocin (STZ)-induced type 2 diabetic mice
한국실험동물학회 학술발표대회 논문집
2019 .07
-
Gene Expression Profiling of Acetaminophen Induced Hepatotoxicity in Mice
Molecular & cellular toxicology
2006 .01
-
Toxicogenomics Study on Carbon Tetrachloride-induced Hepatotoxicity in Mice
Molecular & cellular toxicology
2005 .01
-
Mice vs. Men
한국실험동물학회 학술발표대회 논문집
2016 .08
-
The Top3β gene expressions in adult mouse tissues
한국실험동물학회 학술발표대회 논문집
2014 .08
-
Gene Expression in Rat Hearts Following Oral Administration of a Single Hepatotoxic Dose of Acetaminophen
Yonsei Medical Journal
2012 .01
-
Gene Expression Analysis of Hepatic Response Induced by Gentamicin in Mice
Molecular & cellular toxicology
2007 .01
-
A Unique Gene Expression Signature of 5-fluorouracil
Molecular & cellular toxicology
2005 .01
-
Early Gene Expression in Mouse Spleen Cells after Exposure to Nickel Acetate
Toxicological Research
2006 .06
-
Gene Expression Profile and Its Interpretation in Squamous Cell Lung Cancer
Molecular & cellular toxicology
2006 .01
-
Gene Expression Analysis of Methotrexate-induced Hepatotoxicity between in vitro and in vivo
Molecular & cellular toxicology
2005 .01
-
Use of a Combined Gene Expression Profile in Implementing a Drug Sensitivity Predictive Model for Breast Cancer
Cancer Research and Treatment
2017 .01
-
약-약 상호작용 연구(IV) Warfarin의 혈장단백 결합에 대한 Niflumic Acid 및 Phenylbutazone의 영향 비교
약학회지
1980 .01
-
Profiling of Gene Expression According to Cancer Stage in Clear Cell Type of Renal Cell Carcinoma
Molecular & cellular toxicology
2005 .01
-
Assessment of Biomarkers in Acetaminophen-Induced Hepatic Toxicity by siRNA
Biomolecules & Therapeutics(구 응용약물학회지)
2009 .01
-
Gene Expression Profiling of Early Renal Toxicity Induced by Gentamicin in Mice
Molecular & cellular toxicology
2006 .01
-
Microarray Analysis of the Gene Expression Profile in Diethylnitrosamine-induced Liver Tumors in Mice
한국환경성돌연변이·발암원학회지
2005 .12
-
Global analysis of gene expression in starved mouse liver using oligonucleotide microarray
한국실험동물학회 학술발표대회 논문집
2016 .08
이 논문의 저자 정보
이 논문과 함께 이용한 논문
아세트아미노펜 유도 HepG-2 세포주 손상에 대한 굴 효소 가수분해물의 보호 효과
박시향
,
문성실
,
Cheng-Liang Xie
외 2명
한국식품영양과학회지
2014
.08
아세트아미노펜에 의해 간손상이 유발된 랫드의 유전자 발현 분석
정희경
Toxicological Research
2006
.12
아스피린의 부작용 : 지리의학의 관점에서
조기호
대한지리학회 학술대회논문집
2015
.11
[良方] 아스피린의 효과 - 항암 · 항치매 효과 및 혈전없애 돌연사 · 중풍예방
李旺載
고시계
2007
.09
의약품 사용평가(DUR) 확대를 통한 의약품 부작용 보고 활성화 방안
정수철
한국콘텐츠학회논문지
2019
.01
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2009-513-017213980