지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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Objectives : Nowadays many studies with MRI have reported structural abnormalities of corpus callosum of schizophrenic patients. However, the results are various and inconstant In this study, we attempted to identify structural change of corpus callosum.
Method : We measured the size of corpus callosum of the 24 schizophrenia patients (male 11, female 18) who were diagnosed by DSM-Ⅳ (1994), visited at department of psychiatry, catholic university hospital of Daegu from January 2002 to December 2003, by using midline sagittal slice of MRI. These results were compared with the size of corpus callosum of 25 controls (male 7, female 18). We divided corpus callosum into 7 areas. We calculated and compared the areas of each subregion, mid-sagittal cerebral area, and entire corpus callosum. The results were analyzed by independent t-test.
Result : When we compared subregion to corpus callosum adjusted with mid-sagittal cerebral area, schizophrenia patients had significantly smaller genu (1.64±0.32 vs. 1.43±0.26 ; p＜0.05) and splenium (2.16±0.27 vs. 1.96±0.30 ; p＜0.05). Similarly, the ratio of total corpus callosum to midline sagittal cerebral area (%)(7.50±0.72 vs. 6.90±0 82 ; p<0.05) was significantly smaller in schizophrenia than control group.
Conclusion : In this study, we found significant differences in corpus callosum between schizophrenic patients and normal control group.
Method : We measured the size of corpus callosum of the 24 schizophrenia patients (male 11, female 18) who were diagnosed by DSM-Ⅳ (1994), visited at department of psychiatry, catholic university hospital of Daegu from January 2002 to December 2003, by using midline sagittal slice of MRI. These results were compared with the size of corpus callosum of 25 controls (male 7, female 18). We divided corpus callosum into 7 areas. We calculated and compared the areas of each subregion, mid-sagittal cerebral area, and entire corpus callosum. The results were analyzed by independent t-test.
Result : When we compared subregion to corpus callosum adjusted with mid-sagittal cerebral area, schizophrenia patients had significantly smaller genu (1.64±0.32 vs. 1.43±0.26 ; p＜0.05) and splenium (2.16±0.27 vs. 1.96±0.30 ; p＜0.05). Similarly, the ratio of total corpus callosum to midline sagittal cerebral area (%)(7.50±0.72 vs. 6.90±0 82 ; p<0.05) was significantly smaller in schizophrenia than control group.
Conclusion : In this study, we found significant differences in corpus callosum between schizophrenic patients and normal control group.
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참고문헌
참고문헌 (42)
참고문헌 신청
[학술지(정기간행물)] - / jneurolneurosurgpsychiatry1994 / Lishman WA. Develop-mental abnormalities of the corpus callosum and severe psychiatric disorders : 85 ~ 93
[학술지(정기간행물)] - / / Cohen GA. Developmental abnormalities of the corpus calosum in schizophrenia : 805 ~ 8
[학술지(정기간행물)] - / 1987.p.23-52. / Gruzelier J. Comentary on neuropsychological and information processing deficits in psychosis and neuro-psychophysiological syndrome relationships in schi-zophrenia. In Laterality and Psy-chopathology. Ed by Takahashi R
[학술지(정기간행물)] - / / et al. A controlled magnetic resonance imaging study of corpus calosum thickness in schizophrenia. Biol Psychiatry 1986 : 274 ~ 82
[학술지(정기간행물)] - / / Casac -hia M. Quantification of corpus calosum and ventricles in schizophrenia with neclear magnetic resonance ima-ging : 99 ~ 101
[학술지(정기간행물)] - / / Cohen GA. Developmental abnormalities of the corpus calosum in schizophrenia : 805 ~ 8
[학술지(정기간행물)] - / 1987.p.23-52. / Gruzelier J. Comentary on neuropsychological and information processing deficits in psychosis and neuro-psychophysiological syndrome relationships in schi-zophrenia. In Laterality and Psy-chopathology. Ed by Takahashi R
[학술지(정기간행물)] - / / et al. A controlled magnetic resonance imaging study of corpus calosum thickness in schizophrenia. Biol Psychiatry 1986 : 274 ~ 82
[학술지(정기간행물)] - / / Casac -hia M. Quantification of corpus calosum and ventricles in schizophrenia with neclear magnetic resonance ima-ging : 99 ~ 101
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UCI(KEPA) : I410-ECN-0101-2009-513-017219462