지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
흰쥐유래의 비만세포인 RBL-2H3 세포는 다양한 Src-family kinase를 발현한다. 현재까지의 연구결과에 의하면 비만세포의 초기 활성화에 Lyn kinase가 중요한 역할을 한다고 알려져 왔다. 그러나 그 세포에서 발현되는 다양한 다른 Src-family kinase의 역할은 불분명하다. 본 연구에서는 비만세포에서 다양한 Src-family kinase가 세포내 다른 곳에서 다양하게 발현되고 있다는 사실을 RT-PCR, immunoblotting 그리고 confocal microscopy 기법을 이용하여 증명하였다. 그 결과 Lyn 및 Fgr kinase는 세포막에 위치하고 c-Src 및 Yes kinase는 세포 내 과립에 존재하는 것을 알 수 있었다. 모든 Src-family kinase를 클로닝하고 과발현하여 탈과립 대한 영향을 평가하였다. 그 결과 Fyn과 Fgr kinase는 비만세포에서 항원 유도의 탈과립을 증가시켰으며 반면 Lyn kinsae는 탈과립을 억제시키는 것을 확인할 수 있었다. 이러한 결과는 비만세포 초기 신호전달계에서 Fgr가 중요한 역할을 할 가능성을 제시한다.
목차
Introduction
Materials and Methods
Results
Discussion
Acknowledgement
References
초록
참고문헌 (24)
참고문헌 신청
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El Shazly, A., N. Yamaguchi, K. Masuyama, T. Suda and T. Ishikawa. 1999. Novel association of the SFKs, hck and c-fgr, with CCR3 receptor stimulation: a possible mechanism for eotaxin-induced human eosinophil chemotaxis. Biochem. Biophys. Res. Commun. 264
Gresham, H. D., B. M. Dale, J. W. Potter, P. W. Chang, C. M. Vines, C. A. Lowell, C. F. Lagenaur and C. L. Willman. 2000. Negative regulation of phagocytosis in murine macrophages by the Src kinase family member, Fgr. J. Exp. Med. 191, 515-528.
Brown, F. D., N. Thompson, K. M. Saqid, J. M. Clark, D. Powner, N. T. Thompson, R. Solari and M. J. O. Wakelam. 1998. Phospholipase D1 localizes to secretory granules and lysosomes and is plasma-membrane translocated on cellular stimulation. Curr. Biol. 8
Cissel, D. S., P. F. Fraundorfer and M. A. Beaven. 1998. Thapsigargin-induced secretion is dependent on activation of a cholera toxin-sensitive and a phosphatidylinositol-3-kinase-regulated phospholipase D in a mast cell line. J. Pharmacol. Exp. Ther. 285
El Shazly, A., N. Yamaguchi, K. Masuyama, T. Suda and T. Ishikawa. 1999. Novel association of the SFKs, hck and c-fgr, with CCR3 receptor stimulation: a possible mechanism for eotaxin-induced human eosinophil chemotaxis. Biochem. Biophys. Res. Commun. 264
Gresham, H. D., B. M. Dale, J. W. Potter, P. W. Chang, C. M. Vines, C. A. Lowell, C. F. Lagenaur and C. L. Willman. 2000. Negative regulation of phagocytosis in murine macrophages by the Src kinase family member, Fgr. J. Exp. Med. 191, 515-528.
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