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자료유형
학술저널
저자정보
저널정보
한국독성학회 Toxicological Research Journal of Toxicology and Public Health Vol.23 No.2
발행연도
2007.6
수록면
107 - 114 (8page)

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Although there are some questions about the venues of adult neurogenesis, it is undoubtedly accepted that new neurons are born in adult brains. Adult neurogenesis is regulated by a wide array of factors. Insults harmful to brain, such as neurodegenerative diseases, seizure, ischemia and exposure to drugs of abuse, are intricately related to adult neurogenesis. Whereas neurodegenerative diseases are characterized by death or functional loss of specific neurons, recent studies report that they can be accompanied by neurogenesis. In addition, alcohol and drugs of abuse which have been reputed to cause irreversible damage to brain can also generate newly born cells in adult brain. As yet, however, we have little knowledge of the functional significance and roles of adult neurogenesis under pathological settings, not to mention under physiological settings. Accordingly, in this review we briefly summarize the results of studies which focus on adult neurogenesis in insulted brain, instead of trying to draw hurried conclusion regarding the relationship between adult neurogenesis and brain insults.

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INTRODUCTION
ADULT NEUROGENESIS AND NEURODEGENERATIVE DISEASES
ADULT NEUROGENESIS AND BRAIN INJURY
ADULT NEUROGENESIS AND DRUGS OF ABUSE: OPIATES, PSYCHOSTIMULANTS AND ALCOHOL
CONCLUDING REMARKS
REFERENCES

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