개인구독
소속 기관이 없으신 경우, 개인 정기구독을 하시면 저렴하게
논문을 무제한 열람 이용할 수 있어요.
지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Membrane-type 1 matrix metalloproteinase (MT1-MMP) is a membrane-associated zinc-dependent endoproteinase involved in extracellular matrix remodeling. MT1-MMP hydrolyzes ECM proteins like collagen and is involved in cancer cell migration and metastasis. Caveolins are integral membrane proteins and play a role in formation of caveolae, specialized membrane microdomains involved in clathrin-independent endocytosis. Recombinant MT1-MMP was transiently expressed in PANC-1 cells. Cells expressing recombinant MT1-MMP were able to hydrolyze collagen and migrate on collagen coated trans-well. Both subjacent collagen degradation and the cell migration conferred by recombinant MT1-MMP were inhibited by co-transfection of plasmids containing caveolin-1 cDNA. The results support that MT1-MMP is localized in lipid raft of the membrane and MT1-MMP activities in invasive cells could be inhibited by caveolin.
목차
서론
재료 및 방법
결과 및 고찰
감사의 글
References
참고문헌 (11)
참고문헌 신청
1. [학술지(정기간행물)] - Ohuchi, E. / 1997 / Membrane type 1 matrix metalloproteinase digests interstitial collagens and other extracellular matrix macromolecules / J. Biol. Chem 272 : 2446 ~ 2451
2. [학술지(정기간행물)] - Hottary, K. H / 2000 / Regulation of Cell Invasion and Morphogenesis in a Three-dimensional Type I Collagen Matrix by Membrane-type Matrix Metalloproteinases 1, 2, and 3 / J. Cell Biol 149 : 1309 ~ 1323
3. [학술지(정기간행물)] - Egenlad, M / 2002 / New functions for the matrix metalloproteinases in cancer progression / Nat. Rev. Cancer 2 : 161 ~ 174
4. [학술지(정기간행물)] - Seiki,M / 2002 / The cell surface: the stage for matrix metalloproteinase regulation of migration / Curr. Opin. Cell Biol 14 : 624 ~ 632
5. [학술지(정기간행물)] - Stanton, S. / 1998 / The activation of proMMP-2 (gelatinase A) by HT1080 fibrosarcoma cells is promoted by culture on a fibronectin substrate and is concomitant with an increase in processing of MT1-MMP (MMP14) to a 45kDa form / J. Cell Sci 111 : 2789 ~ 2798
2. [학술지(정기간행물)] - Hottary, K. H / 2000 / Regulation of Cell Invasion and Morphogenesis in a Three-dimensional Type I Collagen Matrix by Membrane-type Matrix Metalloproteinases 1, 2, and 3 / J. Cell Biol 149 : 1309 ~ 1323
3. [학술지(정기간행물)] - Egenlad, M / 2002 / New functions for the matrix metalloproteinases in cancer progression / Nat. Rev. Cancer 2 : 161 ~ 174
4. [학술지(정기간행물)] - Seiki,M / 2002 / The cell surface: the stage for matrix metalloproteinase regulation of migration / Curr. Opin. Cell Biol 14 : 624 ~ 632
5. [학술지(정기간행물)] - Stanton, S. / 1998 / The activation of proMMP-2 (gelatinase A) by HT1080 fibrosarcoma cells is promoted by culture on a fibronectin substrate and is concomitant with an increase in processing of MT1-MMP (MMP14) to a 45kDa form / J. Cell Sci 111 : 2789 ~ 2798
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
참당귀 추출분말이 in vitro and in vivo model에서 MMPs 조절 기전
분석과학
2015 .12
-
헛개나무내의 Matrix Metalloproteinase-9 활성 억제제에 관한 연구
분석과학
2011 .04
-
Regulation of Matrix Metalloproteinase-1 Expression by the Homeodomain Transcription Factor Caudal in Drosophila Intestine
생명과학회지
2012 .12
-
갯메꽃 추출물과 유기용매 분획물의 암전이 억제 효과
생명과학회지
2019 .03
-
Disulfiram에 의한 type Ⅳ collagenase 저해효과
생명과학회지
2006 .10
-
Regulation of expression of matrix metalloproteinase-9 by JNK in Raw 264.7 cells: presence of inhibitory factor(s) suppressing MMP-9 induction in serum and conditioned media
Experimental and Molecular Medicine
2009 .01
-
Inhibitory effects of type Ⅳ collagenase (MMP-9 and MMP-2) by disulfiram on the invasion of human osteosarcoma cells
한국생명과학회 심포지움
2006 .04
-
A functional comparison between the HER2high/HER3 and the HER2low/HER3 dimers on heregulin-β1-induced MMP-1 and MMP-9 expression in breast cancer cells
Experimental and Molecular Medicine
2012 .01
-
miR-526b targets 3′ UTR of MMP1 mRNA
Experimental and Molecular Medicine
2015 .01
-
인간 신장암 Caki세포에서 Par-4에 의한 MMP-2 활성 저해를 통한 세포 이동 조절
생명과학회지
2016 .05
-
오디 추출물의 혈관신생 억제 효과
생명과학회지
2008 .05
-
14-3-3ε protein increases matrix metalloproteinase-2 gene expression via p38 MAPK signaling in NIH3T3 fibroblast cell
Experimental and Molecular Medicine
2009 .01
-
낙우송(Metasequoia glyptostroboides)으로부터 분리한 flavonoid의 금속단백분해효소-9 발현 억제 활성
생명과학회지
2005 .04
-
뇌신경세포에서 tPA에 의한 MMP의 발현 조절에 관한 연구
생명과학회지
2009 .06
-
Sulfolaphane이 lipopolysaccharide (LPS)에 의해 유도된 matrix metalloproteinase-9(MMP-9) 발현에 미치는 영향
생명과학회지
2010 .02
-
항산화 활성을 가진 그래핀이 HT1080 세포에서 기질금속단백질분해효소에 미치는 영향
생명과학회지
2013 .10
-
대황 추출물의 항산화 활성 및 MMP-1 저해 활성
생명과학회지
2008 .12
-
Protective actions of Rubus coreanus ethanol extract on collagenous extracellular matrix in ultraviolet-B irradiation-induced human dermal fibroblasts
Nutrition Research and Practice
2007 .12
-
Protective actions of Rubus coreanus ethanol extract on collagenous extracellular matrix in ultraviolet-B irradiation-induced human dermal fibroblasts
Nutrition Research and Practice
2007 .12
이 논문의 저자 정보
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2009-470-016478101