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초록· 키워드
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Ginseng saponin has been shown to inhibit the development of dependence on morphine, cocaine, methamphetamine, but the antinarcotics effects of ginseng on nalbuphine remains still largely unknown. Ginseng administration attenuated the naloxone-induced jumping behavior on nalbuphine dependent mice. The development of morphine dependence was mediated through μ-opioid receptor, however, development of nalbuphine dependence was mediated through κ-opioid receptor. However, it was found that the efficacy of analgesic antagonism of GTS was mediated through the serotonergic mechanism, not mediated through the opioid receptor. In addition, ginseng administration modulated cellular signal transduction in the brain. The increased NMDA receptor subunit (NR1, pNR1), phosphate extracellular signal regulated protein kinase (pERK), phosphate cAMP response element binding protein (pCREB) expression by nalbuphine was decreased by the administration of ginseng powder in cortex, hippocampus, striatum of rat brain. These results suggest that ginseng could be one of the targets of antinarcotic therapies to reduce the development of tolerance and dependence on nalbuphine as well as morphine.
목차
Abstract
서론
몰핀 중독 억제작용
염산 날부핀에 대한 항마약효과
인삼의 코카인 및 메탐페타민(필로폰)에 대한 항마약효과
인용문헌
참고문헌 (19)
참고문헌 신청
, 1937 , 조선인삼사,5권
Kim,H.S , 1990 , Antinarcotic effects of the standardized ginseng extract G115 on morphine , Planta Med 56 : 158 ~ 162
CoutinhoNetto,J , 1980 , Suppression of evoked and spontaneous release of neurotransmitters in vivo by morphine , Biochem. Pharmacol 29 : 2777 ~ 2780
Aghajanian,G.K , 1994 , Opiate withdrawal increases glutamate and aspartate efflux in the locus coeruleus: an in vivo microdialysis study , Brain Res 636 : 126 ~ 130
Koyuncuoglu,H. , 1992 , Effects of MK801 on morphine physical dependence: attenuation and intensification , Pharmacol. Biochem. Behav 43 : 487 ~ 490
Kim,H.S , 1990 , Antinarcotic effects of the standardized ginseng extract G115 on morphine , Planta Med 56 : 158 ~ 162
CoutinhoNetto,J , 1980 , Suppression of evoked and spontaneous release of neurotransmitters in vivo by morphine , Biochem. Pharmacol 29 : 2777 ~ 2780
Aghajanian,G.K , 1994 , Opiate withdrawal increases glutamate and aspartate efflux in the locus coeruleus: an in vivo microdialysis study , Brain Res 636 : 126 ~ 130
Koyuncuoglu,H. , 1992 , Effects of MK801 on morphine physical dependence: attenuation and intensification , Pharmacol. Biochem. Behav 43 : 487 ~ 490
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Effect of Ginseng Total Saponin on the Development of Psychic and Physical Dependence on Nalbuphine
The journal of applied pharmacology : the official journal of the Korean Society of Applied Pharmacology
1994 .01
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Effects of nalbuphine on the development of morphine-induced tolerance and dependence in rats
대한약학회 학술대회
2002 .01
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Inhibitory Action of the Ginseng Total Saponin on the Nalbuphine-Induced Tolerance and Withdrawal Syndrome
Journal of Ginseng Research
2005 .06
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Inhibitory Action of the Natural Product AP1700 on the Withdrawal Syndrome of Nalbuphine
The journal of applied pharmacology : the official journal of the Korean Society of Applied Pharmacology
2005 .01
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Attenuation of Morphine Tolerance and Withdrawal Syndrome by Coadministration of Nalbuphine
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2006 .01
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Effects of Morphine and Panax ginseng on the Opioid Receptor-G protein Interactions
The journal of applied pharmacology : the official journal of the Korean Society of Applied Pharmacology
1999 .01
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Nalbuphine의 병용투여에 의한 morphine의 내성 및 의존성 형성 저하효과
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비내 수술시 전처치약제로 사용한 Midazolam 단독 투여와Nalbuphine 병용 투여의 효과 비교
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2005 .01
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Protective Effects of Panax ginsengon the Neurotoxicity Induced by Abuse Drugs
고려인삼학회 학술대회
2005 .11
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Effect of Total Ginseng Saponin on the Opioid Receptor Binding in Mouse Brain
Journal of Ginseng Research
1995 .12
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Effects of Panax Ginseng on the Development of Morphine Tolerance and Dependence
Korea-Japan Panax Ginseng Symposium
1987 .09
-
The Effects of Nalbuphine on the Spontaneous locomotor activity and Primary Humoral Immune response in mice.
한국응용약물학회 춘계학술발표논문집
1997 .01
-
Antinarcotic Effect of Panax ginseng
International Symposium on Ginseng
1990 .07
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Spinal Co-Administration of Ginsenosides with Morphine Prevents the Development of Opioid Tolerance and Attenuates Opioid Dependence
Journal of Ginseng Research
1999 .12
-
절개통증모델 흰쥐에서 복강내 Nalbuphine-HCl 투여가 뇌의 C-fos 발현에 미치는 영향
The Korean Journal of Pain
2004 .01
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Effects of Ginseng Saponins on Morphine 6-Dehydrogenase
한국응용약물학회 춘계학술발표논문집
1994 .01
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Effect of Panax ginseng on the Development of Morphine Induced Tolerance and Dependence (VI). On the oral administration of ginseng ether fraction and saponins
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
1987 .01
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