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논문 기본 정보

자료유형
연구보고서
저자정보
저널정보
한국한의학연구원 한국한의학연구원 연구보고서 한국한의학연구원 연구보고서 태반제제의 효능시험 연구
발행연도
2006.12
수록면
1 - 61 (61page)

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The purpose of this study was to examine the effects of the Hominis placenta extracts and Astragali radix extracts on improvement of senile osteoporosis (Type 2) in SAM P6. Placenta ex-tracts (Beuronel<SUP>®</SUP>) produced by INBIONET Corp, Daejeon, Korea is hydrolysate of dried human placenta that contains interferon, prostaglandin E1, lysozyme, glycosaminoglycans (GAG) and various amino acid such as leusine, alanine and glutamic acid. In traditional oriental medicine, Placenta (Jahageo) is indicated for insufficiency of blood and tidal fever due to steaming bone disorder. At 10 weeks after birth, Placenta ex. and Astrali Radix ex. was given 100μL and 200μL/kg/day (i.p.), 3times a week for 4 weeks in SAM P6 mice. We measured complete blood cells (CBC) such as RBC, HGB, Hct, PLT, MPB and MCHC. And we analyzed the plasma concentrations of blood urea nitrogen, creatinine, inorganic phosphate and total iron. In addition, we tested bone mineral density (BMD) using the soft X-ray (Lunar Pixirnus). As a result, in SAM P6, injection of Placenta ex. (200μL) increased in RBC, HB and PLT, in comparison with control group. It was also found that the inorganic phosphate levels increased significantly in the injection groups of the Placenta ex. from that of the control group, but blood urea nitrogen was no significant. Moreover, Placenta ex. and Astrali Radix ex. were showed a trend of increase in bone mineral density (BMD) of the vertebrae lumbales, femur and tibia in P6 mice (Fig. 1). These findings suggest that Placenta ex. and Astragali Radix ex. are effective in preventing bone loss in SAMP6. In conclusion, these extracts help on improvement of osteoporosis in SAMs through probably hematogenous functions.
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Ⅰ. 서론
Ⅱ. 재료 및 방법
Ⅲ. 결과
Ⅳ. 고찰
결론
Abstracts
Ⅴ. 참고문헌

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