지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2007.4
- 수록면
- 139 - 145 (7page)
이용수
초록· 키워드
오류제보하기
Emodin is one of the main active components of a traditional Korean medicine isolated from the root and rhizomes of Rheum palmatum L. In this study, of 222 natural compounds to evaluate the anabolic activities, emodin activated bone morphogenetic protein (BMP)-2 promoter in the differentiation process of mouse osteoblastic MC3T3-E1 cells. Emodin was shown to significantly stimulate the activity and expression of alkaline phosphatase, an earlyphase marker of osteoblastic differentiation, on the differentiation day 7, and induce the osteopontin mRNA expression from the differentiation day 14. In addition, low concentration (up to 5 M) of emodin dramatically promoted the induction of mineralization in MC3T3-E1 subclone 4 cells. The stimulatory effect of emodin on the osteoblast differentiation/mineralization could be associated with its potential to stimulate the BMP-2 gene expression. Although further studies are needed to determine the precise mechanism, this study suggests that the use of herbal medicine containing natural compounds with anabolic activity such as emodin could have a beneficial effect on bone health.
목차
Ⅰ. Introduction
Ⅱ. Materials and methods
Ⅲ. Results
Ⅳ. Discussion
Ⅴ. Acknowledgments
Ⅳ. References
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Aloe-Emodin Induces Chondrogenic Differentiation of ATDC5 Cells via MAP Kinases and BMP-2 Signaling Pathways
Biomolecules & Therapeutics(구 응용약물학회지)
2016 .01
-
The comparative study of Emodin between in vitro genetic toxicity tests and Microarray analysis.
환경독성보건학회 심포지엄 및 학술대회
2007 .05
-
Emodin Induces Apoptosis in Con A Stimulated Primary Immune Cells
한국실험동물학회 학술발표대회 논문집
2014 .02
-
Effects of emodin on ethanol-induced mouse embryonic abnormality in vitro
한국실험동물학회 학술발표대회 논문집
2008 .05
-
Expression Profile of Genes Modulated by Aloe emodin in Human U87 Glioblastoma Cells
Asian Pacific journal of cancer prevention : APJCP
2014 .01
-
Enhancement of bone morphogenetic protein-2 expression and bone formation by Ginsenoside Rd via p38 and AMPK pathway in osteoblasts
고려인삼학회 학술대회
2011 .04
-
호장으로부터 분리한 안트라퀴논류의 Nitric Oxide 저해활성
약학회지
2010 .01
-
Hepatoprotective effect of emodin isolated from Rhei Rhizoma
대한약학회 학술대회
2001 .01
-
Emodin Inhibits Breast Cancer Cell Proliferation through the ERα-MAPK/Akt-Cyclin D1/Bcl-2 Signaling Pathway
Asian Pacific journal of cancer prevention : APJCP
2014 .01
-
Effects of Emodin Extracted from Chinese Herbs on Proliferation of Non-small Cell Lung Cancer and Underlying Mechanisms
Asian Pacific journal of cancer prevention : APJCP
2012 .01
-
Emodin이 polyinosinic-polycytidylic acid로 유발된 인간 신경모세포종 SH-SY5Y의 hydrogen peroxide 생성증가에 미치는 영향
동의생리병리학회지
2011 .12
-
Gene expression pattern during osteogenic differentiation of human periodontal ligament cells in vitro
Journal of Periodontal & Implant Science
2011 .01
-
Lactoferrin augments differentiation potency of osteoblastic MC3T3-E1 cells
한국실험동물학회 학술발표대회 논문집
2015 .08
-
Inhibitory effect of Panax notoginseng and emodin on LPS-induced iNOS, COX-2 and prostaglandin E2
동의생리병리학회지
2006 .06
-
Osteoblast differentiation of human bone marrow stromal cells (hBMSC) according to age for bone tissue engineering
대한구강악안면외과학회지
2010 .01
-
Synergistic Effects of Chios Gum Mastic Extract and Low Level Laser Therapy on Osteoblast Differentiation
International Journal of Oral Biology
2016 .01
-
홍화씨 추출물이 MC3T3-E1 조골세포의 증식과 분화에 미치는 영향
Oral Biology Research
2013 .01
-
조골세포의 분화에 산겨릅나무 추출물이 미치는 영향
대한한의학방제학회지
2017 .01
-
단백질 전달 영역 융합-Bone Morphogenetic Protein-2가 백서 두개골 결손부에서 골 조직 재생에 미치는 효과
Journal of Periodontal & Implant Science
2008 .01
-
The Effects of Recombinant Human BMP-7, Prepared from a COS-7 Expression System, on the Proliferation and Differentiation of Rat Newborn Calvarial Osteoblasts
Yonsei Medical Journal
2003 .01
이 논문의 저자 정보
이 논문과 함께 이용한 논문
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2010-519-001421624