지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.6
- 수록면
- 271 - 274 (4page)
이용수
초록· 키워드
오류제보하기
Chemicals are known to disturb immune system, resulting in various immunopathologic disorders. The chemicals-induced immune modulation has been studied using experimental animals, mostly mice. Meanwhile, in vitro system using animal cell lines has been developed and applied to investigate xenobiotics-mediated immune dysregulation. Imbalance in helper T cell subset activities is known to cause suppression of host defense against pathogenic microorganisms or induction of aberrant hyperreactive responses leading to autoimmune or allergic diseases. The effect of xenobiotics on helper T cell subset reactivities can be investigated through in vitro co-culture system. In the in vitro co-culture system, mouse splenocytes or mouse cell lines expressing appropriate major histocompatibility complex class II haplotype are presenting antigens to helper T clonal cells. Therefore, the in vitro system can be applied to evaluate the influence of xenobiotics on antigen-dependent interactions between antigen presenting cells and helper T cells. Considering recent trends to develop an in vitro model for evaluating toxicity or effectiveness of chemicals, pharmaceutical products, or functional food ingredients, the in vitro co-culture system may be a reasonable candidate to investigate xenobiotics-induced immune modulation.
목차
등록된 정보가 없습니다.
참고문헌 (22)
참고문헌 신청
1. [학술지(정기간행물)] - Ban, M / 2006 / TDI can induce respiratory allergy with TH2- dominated response in mice / Toxicology 218 : 39 ~ 47
2. [학술지(정기간행물)] - Barrie, A.M / 2005 / The interleukin-12 family of cytokines; Therapeutic targets for inflammatory disease mediation / Clin. Appl. Immunol. Rev 5 : 225 ~ 240
3. [학술지(정기간행물)] - Cherwinski, H.M / 1987 / Two types of mouse helper T cell clone III. Further differences in lymphokine synthesis between Th1 and Th2 clones revealed by RNA hybridization, functionally monospecific bioassays, and monoclonal antibodies / J. Exp. Med 166 : 1229 ~ 1244
4. [학술지(정기간행물)] - Coward, W / 2006 / Effect of atorvastatin on TH1 and TH2 cytokine secreting cells during T cell activation and differentiation / Atherosclerosis 186 : 302 ~ 309
5. [학술지(정기간행물)] - Doria, A / 2006 / Th2 immune deviation induced by pregnancy: The two faces of autoimmune rheumatic diseases / Reprod. Toxicol 22 : 234 ~ 241
2. [학술지(정기간행물)] - Barrie, A.M / 2005 / The interleukin-12 family of cytokines; Therapeutic targets for inflammatory disease mediation / Clin. Appl. Immunol. Rev 5 : 225 ~ 240
3. [학술지(정기간행물)] - Cherwinski, H.M / 1987 / Two types of mouse helper T cell clone III. Further differences in lymphokine synthesis between Th1 and Th2 clones revealed by RNA hybridization, functionally monospecific bioassays, and monoclonal antibodies / J. Exp. Med 166 : 1229 ~ 1244
4. [학술지(정기간행물)] - Coward, W / 2006 / Effect of atorvastatin on TH1 and TH2 cytokine secreting cells during T cell activation and differentiation / Atherosclerosis 186 : 302 ~ 309
5. [학술지(정기간행물)] - Doria, A / 2006 / Th2 immune deviation induced by pregnancy: The two faces of autoimmune rheumatic diseases / Reprod. Toxicol 22 : 234 ~ 241
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UCI(KEPA) : I410-ECN-0101-2009-510-014844133