지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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Esculetin, a coumarin compound, has been known to inhibit proliferation and induce apoptosis in several types of human cancer cells. However, the molecular mechanisms involved in esculetin-induced apoptosis are still uncharacterized in human leukemia cells. In this study, we have investigated whether esculetin exerts anti-proliferative and apoptotic effects on human leukemia U937 cells. It was found that esculetin could inhibit cell viability in a time-dependent manner, which was associated with the induction of apoptotic cell death such as increased populations of apoptotic-sub G1 phase. Apoptosis of U937 cells by esculetin was associated with an inhibition of Bcl-2/Bax binding activity, formation of tBid, down-regulation of X-linked inhibitor of apoptotic protein (XIAP) expression, and up-regulation of death receptor 4 (DR4) and FasL expression. Esculetin treatment also induced the degradation of β-catenin and DNA fragmentation factor 45/inhibitor of caspase-activated DNase (DFF45/ICAD). Furthermore, a caspase-3 specific inhibitor, z-DEVD-fmk, significantly inhibited sub-G1 phase DNA content, morphological changes and degradation of β-catenin and DEE45/ICAD. These results indicated that a key regulator in esculetin-induced apoptosis was caspase-3 in human leukemia U937 cells.
목차
서론
재료 및 방법
결과
고찰
감사의 글
References
참고문헌 (31)
참고문헌 신청
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2. [학술지(정기간행물)] - Ashkenazi, A. / 2002 / Targeting death and decoy receptors of the tumour-necrosis factor superfamily / Nat. Rev. Cancer 2 : 420 ~ 430
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4. [학술지(정기간행물)] - Coultas, L. / 2003 / The role of the Bcl-2 protein family in cancer / Semin. Cancer Biol. 13 : 115 ~ 123
5. [학술지(정기간행물)] - Debatin, K. M. / 2004 / Death receptors in chemotherapy and cancer / Oncogene 23 : 2950 ~ 2966
2. [학술지(정기간행물)] - Ashkenazi, A. / 2002 / Targeting death and decoy receptors of the tumour-necrosis factor superfamily / Nat. Rev. Cancer 2 : 420 ~ 430
3. [학술지(정기간행물)] - Bratton, S. B. / 2001 / Recruitment, activation and retention of caspases-9 and -3 by Apaf-1 apoptosome and associated XIAP complexes / EMBO J. 20 : 998 ~ 1009
4. [학술지(정기간행물)] - Coultas, L. / 2003 / The role of the Bcl-2 protein family in cancer / Semin. Cancer Biol. 13 : 115 ~ 123
5. [학술지(정기간행물)] - Debatin, K. M. / 2004 / Death receptors in chemotherapy and cancer / Oncogene 23 : 2950 ~ 2966
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