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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.3
- 수록면
- 33 - 41 (9page)
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초록· 키워드
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Among the toxicants in the environment dioxin-like compounds, including TCDD(2,3,7,8-Tetrachlorodibenzo-p-Dioxin), are well known as carcinogen and teratogen. TCDD the most toxic of these compounds, may result in a wide variety of adverse health effects in humans and environment, including carconogenesis, hepatotoxicity, teratogenesis, and immunotoxicity. Also TCDD increases superoxide, peroxide radicals and induces oxidative stress that leads to breakage of DNA single-strand and mitochondrial dysfunction. Recently, there have been reports that persistent organic pollutants (POPs) may be causing metabolic disease through mitochondrial toxicity. In order to examine if dioxin brings about toxicity on mitochondria directly, we measured the change of the mitochondrial membrane potential after exposure to TCDD using JC-1 dye. After short time exposure of dioxin, mitochondrial depolarization was observed but it recovered to the control level immediately. This TCDD effect on mitochondrial membrane potential was not correlated either to the production of reactive oxygen species (ROS) or extracellular Ca²? by TCDD.
Less than 2 hours exposure of TCDD did not show any change in ROS production but 0.25 nM TCDD for 48 hours or 0.5 nM TCDD for 12 hours exposure did increase in ROS production. Under these conditions of ROS production by TCDD, no changes in the mitochondrial membrane potential by TCDD was observed.
Less than 2 hours exposure of TCDD did not show any change in ROS production but 0.25 nM TCDD for 48 hours or 0.5 nM TCDD for 12 hours exposure did increase in ROS production. Under these conditions of ROS production by TCDD, no changes in the mitochondrial membrane potential by TCDD was observed.
목차
ABSTRACT
서론
재료 및 방법
결과
고찰
참고문헌
참고문헌 (18)
참고문헌 신청
1. [학술지(정기간행물)] - Arisawa K / 2005 / Background exposure to PCDDs/PCDFs/PCBs and its potential health effects: a review of epidemiologic studies / J Med Invest 52 (1) : 10 ~ 21
2. [학술지(정기간행물)] - Biswas G / 2008 / Dioxin-mediated tumor progression through activation of mitochondria-to-nucleus stress signaling / Proc Natl Acad Sci USA 105 (1) : 186 ~ 191
3. [학술지(정기간행물)] - Carosio R / 2007 / Sodium ascorbate induces apoptosis in neuroblastoma cell lines by interfering with iron uptake / Mol Cancer 6 : 55 ~
4. [학술지(정기간행물)] - Davis D / 1990 / Immunosuppressive activities of polychlorinated biphenyls in C57BL/6N mice: structure-activity relationships as Ah receptor agonists and partial antagonists / Toxicology 63 (1) : 97 ~ 111
5. [학술지(정기간행물)] - Hassoun EA / 2002 / Induction of oxidative stress in the tissues of rats after chronic exposure to TCDD, 2,3,4,7,8-pentachlorodibenzofuran, and 3,3′,4,4′,5-pentachlorobiphenyl / J Toxicol Environ Health A 65 (12) : 825 ~ 842
2. [학술지(정기간행물)] - Biswas G / 2008 / Dioxin-mediated tumor progression through activation of mitochondria-to-nucleus stress signaling / Proc Natl Acad Sci USA 105 (1) : 186 ~ 191
3. [학술지(정기간행물)] - Carosio R / 2007 / Sodium ascorbate induces apoptosis in neuroblastoma cell lines by interfering with iron uptake / Mol Cancer 6 : 55 ~
4. [학술지(정기간행물)] - Davis D / 1990 / Immunosuppressive activities of polychlorinated biphenyls in C57BL/6N mice: structure-activity relationships as Ah receptor agonists and partial antagonists / Toxicology 63 (1) : 97 ~ 111
5. [학술지(정기간행물)] - Hassoun EA / 2002 / Induction of oxidative stress in the tissues of rats after chronic exposure to TCDD, 2,3,4,7,8-pentachlorodibenzofuran, and 3,3′,4,4′,5-pentachlorobiphenyl / J Toxicol Environ Health A 65 (12) : 825 ~ 842
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논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
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Changes in Gene Expression by 2,3,7,8-Tetrachlorodibenzo-p-Dioxin in the Liver of C57BL/6 Mice
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사람의 정상 피부세포 및 폐세포의 발암에 미치는 2,3,7,8-tetrachlorodibenzo-ρ -dioxin의 영향
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Effect of Korean Red Ginseng Crude Saponin on Blood Chemical Parameters of Guinea Pigs Exposed to TCDD
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2003 .03
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2,3,7,8-tetrachlorodibenzo-p-dioxin 노출과 관련한 인체면역기능 변화를 판단할 수 있는 지표치 개발에 관한 연구
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2002 .06
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2,3,7,8-TCDD의 세포형질전환 및 내성획득에 관여하는 세포내 인자에 관한 연구
한국환경성돌연변이·발암원학회지
2006 .03
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랫드에서 TCDD 투여에 의해 유도된 생체독성의 고려홍삼 추출물에 의한 억제 효과
Journal of Ginseng Research
2008 .12
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Environmental Pollution and Gene Expression: Dioxin
Molecular & cellular toxicology
2005 .01
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홍삼유출액으로부터 분리한 조사포닌이 TCDD (2,3,7,8-Tetrachlorodibenzo-ρ-dioxin)로 급성독성을 유도한 흰쥐의 혈액 생화학지수에 미치는 영향
Journal of Ginseng Research
2006 .03
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Mitogen-activated protein kinase signaling pathway mediates 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced apoptosis in Jurkat T cells.
대한약학회 학술대회
2003 .01
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Chemical Transformation of Human Keratinocytes by 2,3,7,8-Tetrachlorodibenxo-ρ-dioxin
한국환경성돌연변이·발암원학회지
2006 .09
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Effect of Crude Ginseng Saponin on Clinical Pathological Parameters of the Female Adult Guinea Pigs Exposed to 2,3,7,8- Tetrachlorodibenzo-p-dioxin
대한의생명과학회지
2001 .12
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Protective Effect of Panax ginseng on TCDD-induced Liver Toxicity in Male Guinea Pigs
대한의생명과학회지
2003 .03
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The comparative study of TCDD between in vitro genetic toxicity tests and Microarray analysis
환경독성보건학회 심포지엄 및 학술대회
2008 .05
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In Utero Exposure to 2,3,7,8-Tetrachlorodibenzo-p-Dioxin Affects the Development of Reproductive System in Mouse
Yonsei Medical Journal
2008 .01
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TCDD (2,3,7,8-tetrachlorodibenzodioxin)로 급성독성을 유도한 자성 기니픽의 대퇴골 무게감소에 대한 홍삼사포닌의 방어효과
Journal of Ginseng Research
2006 .09
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수컷 백서에서 2,3,7,8-tetrachlorodibenzo-p-dioxin-유도독성에 대한 홍삼 및 북미삼의 방어 효과의 병리학적 비교
Journal of Pathology and Translational Medicine
2006 .01
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UCI(KEPA) : I410-ECN-0101-2009-539-019521258