지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.6
- 수록면
- 135 - 138 (4page)
이용수
초록· 키워드
오류제보하기
Thimerosal has been used as an additive to biologics and vaccines because it is very effective in killing bacteria used in several vaccines and in preventing bacterial contamination. However, the toxic mechanism of thimerosal has not been cleared. The present studies were performed to investigate its cytotoxicity and toxic mechanisms. Thimerosal induced cytotoxicity and inhibited the proliferation and differentiation of the midbrain cells. The reactive oxygen species (ROS) generation was increased by thimerosal treatments. However, antioxicants, such as vitamin E and propyl gallate, protected the oxidative damage on midbrain cells and was recovered midbrain cell proliferation and differentiation. These results suggest that antioxidants provide protection of midbrain cells against cytotoxicity induced by thimerosal by facilitating cellular functions that reduce oxidative stress.
목차
재료 및 방법
결과
고찰
참고문헌
참고문헌 (21)
참고문헌 신청
1. [학술지(정기간행물)] - Bernard, S. / 2001 / Autism: a novel form of mercury poisoning / Med. Hypotheses 56 : 462 ~ 471
2. [학술지(정기간행물)] - Castoldi, A.F. / 2001 / Neurotoxicity and molecular effects of methylmercury / Brain Res. Bull 55 : 197 ~ 203
3. [학술지(정기간행물)] - Cosenza, M.E. / 1995 / Effects of chlorpyrifos on neuronal development in rat embryo midbrain micromass cultures / Vet. Hum. Toxicol 37 : 118 ~ 121
4. [학술지(정기간행물)] - Elferink, J.G. / 1999 / Thimerosal: A versatile sulfhydryl reagent, calcium mobilizer, and cell function-modulating agent / Gen. Pharmacol 33 : 1 ~ 6
5. [학술지(정기간행물)] - Flint, O.P. / 1983 / micromass culture method for rat embryonic neyral cells / J. Cell Sci 61 : 247 ~ 262
2. [학술지(정기간행물)] - Castoldi, A.F. / 2001 / Neurotoxicity and molecular effects of methylmercury / Brain Res. Bull 55 : 197 ~ 203
3. [학술지(정기간행물)] - Cosenza, M.E. / 1995 / Effects of chlorpyrifos on neuronal development in rat embryo midbrain micromass cultures / Vet. Hum. Toxicol 37 : 118 ~ 121
4. [학술지(정기간행물)] - Elferink, J.G. / 1999 / Thimerosal: A versatile sulfhydryl reagent, calcium mobilizer, and cell function-modulating agent / Gen. Pharmacol 33 : 1 ~ 6
5. [학술지(정기간행물)] - Flint, O.P. / 1983 / micromass culture method for rat embryonic neyral cells / J. Cell Sci 61 : 247 ~ 262
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Thimerosal의 발생독성에 관한 연구
Toxicological Research
2003 .12
-
백신에 포함된 Thimerosal 및 백신과 관련된 논의들
Pediatric Infection and Vaccine
2001 .01
-
Thimerosal generates superoxide anion by activating NADPH oxidase: a mechanism of thimerosal-induced calcium release
한국환경성돌연변이·발암원학회지
2002 .12
-
백신에 함유된 시메로살의 안전성
Pediatric Infection and Vaccine
2005 .01
-
흰쥐 배양 전배자 및 중뇌세포에서 Ochratoxin A의 독성
약학회지
1998 .01
-
15-Deoxy-$PGJ_2$ Stimulates Neuronal Differentiation of Embryonic Midbrain Cells by Up-regulation of PPAR-gamma Activity via the JNK-dependent Pathway
대한약학회 학술대회
2003 .01
-
중뇌경색에서 발생한 단독 하직근 마비
대한뇌졸중학회지
2011 .01
-
뇌낭미충증으로 인한 진행성 중뇌 증후군 1례
대한뇌졸중학회지
1999 .01
-
Isolated Medial Rectus Palsy in Midbrain Microbleed
대한뇌졸중학회지
2009 .01
-
중뇌 경색 이후 발생한 병적 웃음과 울음 환자: 증례 보고 및 문헌 고찰
한방재활의학과학회지
2018 .01
-
Relationship between activation of transcription factors and neurite outgrowth of embryonic midbrain cells exposed by ochratoxin A
대한약학회 학술대회
2001 .01
-
PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA AGONIST 15-DEOXY-PROSTAGLANDIN J2 STIMULATES DIFFERENTIATION OF EMBRYONIC MIDBRAIN CELLS
대한약학회 학술대회
2002 .01
-
중뇌종양에 의한 적핵진전에 대한 Vim 시상핵절제술 - 증례보고 -
대한신경외과학회지
2000 .01
-
Partial Fascicular Oculomotor Nerve Palsy due to Midbrain Hemorrhage
대한뇌졸중학회지
2007 .01
-
Management of Severe Bilateral Ptosis in a Patient With Midbrain Infarction: A Case Report
Annals of Rehabilitation Medicine
2013 .01
-
정중곁 중뇌경색으로 인한 편측 안검하수에 대한 치험 1례
대한한방내과학회지
2019 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2009-510-018537626