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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.12
- 수록면
- 371 - 376 (6page)
이용수
초록· 키워드
오류제보하기
Perfluorooctanoic acid (PFOA) is a widely used industrial chemical that induces reproductive toxicities. To gain a better understanding of the mechanism underlying the PFOA-induced spermatogenesis impairment, we investigated the effects of PFOA on spermatogenesis and germ cell apoptosis. Ten-week-old Sprague- Dawley rats were treated with PFOA 10 ㎎/㎏/day for 1 day or 5 ㎎/㎏/day for 3 days orally. Rats were euthanized in 12 hrs and 1, 2, 3 and 7 days after treatment. The effects of PFOA on the testes were examined by determining apoptosis and the possible role for Fas and Fas ligand (Fas-L) in atrophy of the testes by histopathology, TUNEL assays and immunoblot. PFOA administration did not lead to significant changes in body and testicular weights. All doses of PFOA showed similar pathological changes in the testes. Degeneration and apoptosis of germ cells was evident in 12 hr of PFOA treatment and progressively increased in a time-dependent manner until 2 days and then slightly decreased at 3 and 7 days after PFOA treatment. Fas and Fas-L protein levels were increased. Collectively, these data suggest that impaired spermatogenesis after PFOA treatment is associated with an increase in germ cell apoptosis and Fas and Fas-L play a significant role in the initiation and/or progression of PFOA-induced testicular damage.
목차
Materials and Methods
Results
Discussion
Acknowledgment
References
참고문헌 (27)
참고문헌 신청
1. [학술지(정기간행물)] - Apelberg, B.J. / 2007 / Cord serum concentrations of perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA) in relation to weight and size at birth / Environ. Health Perspect 115 : 1670 ~ 1676
2. [학술지(정기간행물)] - Biegel, L,B. / 1995 / Effects of ammonium perfluorooctanoate on Leydig cell function: in vitro, in vivo, and ex vivo studies / Toxicol. Appl. Pharmacol 134 : 18 ~ 25
3. [학술지(정기간행물)] - Catalano, S. / 2007 / Fas ligand expression in TM4 Sertoli cells is enhanced by estradiol "in situ" production / J. Cell Physiol 211 : 448 ~ 456
4. [학술지(정기간행물)] - Delbès, G. / 2004 / Estrogen receptor betamediated inhibition of male germ cell line development in mice by endogenous estrogens during perinatal life / Endocrinology 145 (7) : 3395 ~ 3403
5. [학술지(정기간행물)] - Giesy, J.P. / 2002 / Perfluorochemical surfactants in the environment / Environ. Sci. Technol 36 : 146A ~ 152A
2. [학술지(정기간행물)] - Biegel, L,B. / 1995 / Effects of ammonium perfluorooctanoate on Leydig cell function: in vitro, in vivo, and ex vivo studies / Toxicol. Appl. Pharmacol 134 : 18 ~ 25
3. [학술지(정기간행물)] - Catalano, S. / 2007 / Fas ligand expression in TM4 Sertoli cells is enhanced by estradiol "in situ" production / J. Cell Physiol 211 : 448 ~ 456
4. [학술지(정기간행물)] - Delbès, G. / 2004 / Estrogen receptor betamediated inhibition of male germ cell line development in mice by endogenous estrogens during perinatal life / Endocrinology 145 (7) : 3395 ~ 3403
5. [학술지(정기간행물)] - Giesy, J.P. / 2002 / Perfluorochemical surfactants in the environment / Environ. Sci. Technol 36 : 146A ~ 152A
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UCI(KEPA) : I410-ECN-0101-2010-510-001694200