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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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Hesperidin, a member of the flavanone group of flavonoids, can be isolated in large amounts from the rinds of some citrus species [e.g., Citrus aurantium L. (bitter orange), Citrus sinensis L. (sweet orange) and Citrus unshiu Marcov. (satsuma mandarin)], and has been reported to have anticarcinogenic, antihypotensive and antimicrobial properties. Despite the efficacy of these polyphenolic compounds as immune modulators, the effects of the flavonoids are poorly understood about allergic effect. In this study, we investigated whether hesperidin could influence on Th1 and Th2 balance. Allergic reactions included an increase in the number of eosinophils in bronchoalveolar lavage (BAL) fluid, an increase in inflammatory cell infiltration into the lung tissue around blood vessels and airways, airway luminal narrowing, the development of airway hyper-responsiveness (AHR). The administration of hesperidin before the last airway OVA challenge resulted in a significant inhibition of all asthmatic reactions. Accordingly, this study may provide evidence that hesperidin plays a critical role in the amelioration of the pathogenetic process of asthma in mice. These findings provide new insight into the immunopharmacological role of hesperidin in terms of its effects in a murine model of asthma, and also broaden current perspectives in our understanding of the immunopharmacological functions of hesperidin.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
Acknowledgements
REFERENCES
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The Effects of Hesperidin on the Proliferation and Activity of Bone Cells
International Journal of Oral Biology
2006 .01
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Enhanced Bioavailability of Verapamil after Oral Administration with Hesperidin in Rats
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
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Hesperidin Induces Apoptosis in SNU-668, Human Gastric Cancer Cells
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Hesperidin Attenuates Ultraviolet B-Induced Apoptosis by Mitigating Oxidative Stress in Human Keratinocytes
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Hesperidin Induces Apoptosis by Inhibiting Sp1 and Its Regulatory Protein in MSTO-211H Cells
Biomolecules & Therapeutics(구 응용약물학회지)
2012 .01
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$^1H-NMR$을 이용한 한약재의 품질 평가 방법 확립;진피의 Hesperidin 정량분석
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Hesperidin improves the motor disability in rat spinal cord injury through its antioxidant properties
한국실험동물학회 학술발표대회 논문집
2018 .07
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Chemoprotective Effects of Hesperidin Against Genotoxicity Induced by Cyclophosphamide in Mice Bone Marrow Cells
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2008 .01
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Hesperidin Suppresses Melanosome Transport by Blocking the Interaction of Rab27A-Melanophilin
Biomolecules & Therapeutics(구 응용약물학회지)
2013 .01
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진피류(陳皮類) 한약재의 Hesperidin과 정유성분 비교
대한본초학회지(본초분과학회지)
2008 .01
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Antioxidant and Neuroprotective Effects of Hesperidin and its Aglycone Hesperetin
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2006 .01
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Anti-cancer and Anti-inflammatory Properties of Korean Citrus Fruits (Citrus aurantium L.)
한국임상보건과학회지
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Hesperidin improves warm ischemia/reperfusion-induced oxidative renal injury in rats
Oriental pharmacy and experimental medicine
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Natural Products for Cancer-Targeted Therapy: Citrus Flavonoids as Potent Chemopreventive Agents
Asian Pacific journal of cancer prevention : APJCP
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UCI(KEPA) : I410-ECN-0101-2010-510-002463749