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Acute and Subchronic Inhalation Toxicity Evaluation of Methyl Formate in Rats
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Methyl formate의 랫드를 이용한 급성 및 아만성 흡입독성 평가

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Type
Academic journal
Author
Hyeon-Yeong Kim (산업안전보건연구원) Sung-Bae Lee (산업안전보건연구원) Jeong-Hee Han (산업안전보건연구원) Min-Gu Kang (산업안전보건연구원) Jeong-Sun Yang (산업안전보건연구원)
Journal
The Korean Society of Environmental Toxicology Environmental Analysis Health and Toxicology Vol.25 No.2 KCI Accredited Journals SCOPUS
Published
2010.6
Pages
131 - 143 (13page)

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Acute and Subchronic Inhalation Toxicity Evaluation of Methyl Formate in Rats
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We performed the tests of acute and subchronic inhalation toxicity of methyl formate, which has limited toxicological data in spite of its widespread use and enhanced hazard consequent on its high volatility. The median lethal concentration (LC<SUB>50</SUB>) was evaluated to be above 5,000 ppm (12.27 ㎎/L).
In the test with subchronic inhalation, there are no deaths, but with reduction of body weight, food intake, organ weight by exposure to 400 (0.98 ㎎/L) and 1,600 (3.92 ㎎/L) ppm, dose-dependently. There were statistical differences in some hematological and blood biochemical parameters as compared to control (e.g. neutrophile and lymphocyte in the 1,600 ppm group, calcium and A/G in 1,600 ppm group).
Methyl formate under the exposure of 1,600 ppm showed the respiratory findings with nasal, it was confirmed that the chemical has respiratory hazard with 1,600 ppm inhalation exposure, induces nasal epithelial atrophy, olfactory cell degeneration/regeneration and the contraction of olfactory cells, etc.
According to the notification with Ministry of Labor (No. 2009-68) for classification, labeling and MSDS of chemicals, it is suggested for methyl formate to be classified as category 4 in acute (10.0 ＜ category 4≤20.0 ㎎/L), category 2 (0.2 ＜ concentration ~ 1.0 ㎎/L/6h, 90 days) in specific target organ-repeated exposure.
#Methyl formate #Inhalation toxicity #LC< #SUB> #50< #/SUB>

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김현영, 이성배, 강민구, 송시환. 메틸사이클로핵산 (methylcyclohexane)의 흡입독성과 유해성 평가. Environmental Analysis Health and Toxicology. 2006 dbpia

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UCI(KEPA) : I410-ECN-0101-2010-539-003145832