지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.8
- 수록면
- 167 - 179 (13page)
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초록· 키워드
오류제보하기
Objective : The present study has been undertaken to investigate the preventive effects of Daekumeumja on fatty degeneration of liver and immunosuppression induced by alcohol in rats.
Method : Except for the normal group, we fed rat on 25% alcohol for 55 days. And Daekumeumja(DK) extract was administrated for the same period. We measured the serum component in rat's blood, weight of internal organs, liver triglyceride contents, histomorphometry and histopathological observation of internal organs.
Results : 1. In the change measurement of serum components, DK group(50 ㎎/㎏, 200 ㎎/㎏) showed significant decrease of AST, ALT, albumin, ALP and triglyceride in comparison with those of the alcohol control group.
2. In the change measurement of internal organ's weight, DK group(50 ㎎/㎏, 200 ㎎/㎏) showed significant increase of relative body weights of liver, thymus and spleen in comparison with those of the alcohol control group.
3. DK group(50 ㎎/㎏, 200 ㎎/㎏) showed significant decrease of hepatic triglyceride contents in comparison with those of the alcohol control group.
4. In histomorphometrical changes of liver, DK group(50 ㎎/㎏, 200 ㎎/㎏) showed significant decrease of numbers of hepatocytes occupied by over 10 % lipid droplets, percentages of regions occupied by lipid droplets and mean diameters of hepatocytes in comparison with those of the alcohol control group. In histomorphometrical changes of thymus, DK group(50 ㎎/㎏, 200 ㎎/㎏) showed significant increase of lobular thickness and cortex thickness in comparison with those of the alcohol control group. In histomorphometrical changes of spleen, DK group(50 ㎎/㎏, 200 ㎎/㎏) showed significant increase of splenic thicknesses, numbers of white pulps and mean diameters of white pulps in comparison with those of the alcohol control group.
5. In histopathological changes of liver, DK group(50 ㎎/㎏, 200 ㎎/㎏) showed effective inhibition of severe fatty changes in comparison with those of the alcohol control group. In histopathological changes of thymus and spleen, DK group(50 ㎎/㎏, 200 ㎎/㎏) showed effective inhibition of atrophic changes in comparison with those of the alcohol control group.
Conclusions : Reviewing these experimental results, it appears that Daekumeumja have pharmaceutical preventive efficacy on fatty degeneration of liver and immunosuppression induced by alcohol in rats.
Method : Except for the normal group, we fed rat on 25% alcohol for 55 days. And Daekumeumja(DK) extract was administrated for the same period. We measured the serum component in rat's blood, weight of internal organs, liver triglyceride contents, histomorphometry and histopathological observation of internal organs.
Results : 1. In the change measurement of serum components, DK group(50 ㎎/㎏, 200 ㎎/㎏) showed significant decrease of AST, ALT, albumin, ALP and triglyceride in comparison with those of the alcohol control group.
2. In the change measurement of internal organ's weight, DK group(50 ㎎/㎏, 200 ㎎/㎏) showed significant increase of relative body weights of liver, thymus and spleen in comparison with those of the alcohol control group.
3. DK group(50 ㎎/㎏, 200 ㎎/㎏) showed significant decrease of hepatic triglyceride contents in comparison with those of the alcohol control group.
4. In histomorphometrical changes of liver, DK group(50 ㎎/㎏, 200 ㎎/㎏) showed significant decrease of numbers of hepatocytes occupied by over 10 % lipid droplets, percentages of regions occupied by lipid droplets and mean diameters of hepatocytes in comparison with those of the alcohol control group. In histomorphometrical changes of thymus, DK group(50 ㎎/㎏, 200 ㎎/㎏) showed significant increase of lobular thickness and cortex thickness in comparison with those of the alcohol control group. In histomorphometrical changes of spleen, DK group(50 ㎎/㎏, 200 ㎎/㎏) showed significant increase of splenic thicknesses, numbers of white pulps and mean diameters of white pulps in comparison with those of the alcohol control group.
5. In histopathological changes of liver, DK group(50 ㎎/㎏, 200 ㎎/㎏) showed effective inhibition of severe fatty changes in comparison with those of the alcohol control group. In histopathological changes of thymus and spleen, DK group(50 ㎎/㎏, 200 ㎎/㎏) showed effective inhibition of atrophic changes in comparison with those of the alcohol control group.
Conclusions : Reviewing these experimental results, it appears that Daekumeumja have pharmaceutical preventive efficacy on fatty degeneration of liver and immunosuppression induced by alcohol in rats.
목차
Ⅰ. 서론
Ⅱ. 재료 및 방법
Ⅲ. 결과
Ⅳ. 고찰
Ⅴ. 결론
參考文獻
참고문헌 (45)
참고문헌 신청
1. [학술지(정기간행물)] - 오상우 / 2009 / 음주가 비만 및 대사증후군에 미치는 영향 / 대한비만학회지 18 (1) : 1 ~ 7
2. [학술대회논문] - 정영호 / 2009 / 흡연, 음주, 비만에 기인한 질병의 사회 경제적 비용 및 관련품목 조세제도 / 한국사회보장 학회 춘계학술대회 자료집 : 275 ~ 309
3. [학위논문] - 유옥순 / 1997 / 알코올 섭취자와 비섭취자의 영양섭취실태 및 혈청 지 질수준에 대한 비교연구 / 석사 / 공주대학교
4. [학술지(정기간행물)] - William M.H / 1972 / Effect of small and moderate doses of alcohol on exercise heart rate and oxygen consumption / Res Q. 43 (1) : 94 ~ 104
5. [학술지(정기간행물)] - Lieber C. S / 1991 / Hepatic, metabolic and toxic effects of ethanol:1991 update / Alcohol Clin. Exp. Res 15 : 573 ~ 592
2. [학술대회논문] - 정영호 / 2009 / 흡연, 음주, 비만에 기인한 질병의 사회 경제적 비용 및 관련품목 조세제도 / 한국사회보장 학회 춘계학술대회 자료집 : 275 ~ 309
3. [학위논문] - 유옥순 / 1997 / 알코올 섭취자와 비섭취자의 영양섭취실태 및 혈청 지 질수준에 대한 비교연구 / 석사 / 공주대학교
4. [학술지(정기간행물)] - William M.H / 1972 / Effect of small and moderate doses of alcohol on exercise heart rate and oxygen consumption / Res Q. 43 (1) : 94 ~ 104
5. [학술지(정기간행물)] - Lieber C. S / 1991 / Hepatic, metabolic and toxic effects of ethanol:1991 update / Alcohol Clin. Exp. Res 15 : 573 ~ 592
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UCI(KEPA) : I410-ECN-0101-2010-519-002823900