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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.12
- 수록면
- 331 - 337 (7page)
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초록· 키워드
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The rate-limiting step of dietary calcium absorption in the intestine requires the brush border calcium entry channel transient receptor potential vanilloid 6 (TRPV6). The putatively-selected TRPV6 haplotype contains three candidate sites for functional differences, namely derived non-synonymous substitutions C157R, M378V and M681T. Functional electrophysiological characteristics between wild-type and mutant (C157R, M378V and M681T) TRPV6 proteins were investigated by cloning the mutant TRPV6 forms, transfecting cell lines, and carrying out electrophysiology experiments via patch clamp analysis. No statistically significant differences in biophysical channel function were found although one property, namely Ca<SUP>2+</SUP>-dependent inactivation, may show functionally-relevant differences between the wild-type and mutant TRPV6 proteins. This study shows that Ca<SUP>2+</SUP>-dependent inactivation is one of the good differentiation characteristics in TRPV6, and will be useful in an advancing our knowledge about TRPV6.
목차
Materials and Methods
Results
Discussion
Acknowledgment
References
참고문헌 (28)
참고문헌 신청
1. [학술지(정기간행물)] - Altshuler, D. / 2005 / International HapMap-Consortium A haplotype map of the human genome / Nature 437 (7063) : 1299 ~ 1320
2. [학술지(정기간행물)] - Akey, J.M. / 2004 / Population history and natural selection shape patterns of genetic variation in 132 Genes / PLoS Biol. 2 : e286 ~
3. [학술지(정기간행물)] - Akey, J.M. / 2006 / TRPV6 exhibits unusual patterns of polymorphism and divergence in worldwide populations / Hum. Mol. Genet. 15 (13) : 2106 ~ 2113
4. [학술지(정기간행물)] - Birnbaumer, L. / 2003 / A comparison of the genes coding for canonical TRP channels and their M, V and P relatives / Cell Calcium 33 (5-6) : 419 ~ 432
5. [학술지(정기간행물)] - Clapham, D.E. / 2003 / TRP channels as cellular sensors / Nature 426 (6966) : 517 ~ 524
2. [학술지(정기간행물)] - Akey, J.M. / 2004 / Population history and natural selection shape patterns of genetic variation in 132 Genes / PLoS Biol. 2 : e286 ~
3. [학술지(정기간행물)] - Akey, J.M. / 2006 / TRPV6 exhibits unusual patterns of polymorphism and divergence in worldwide populations / Hum. Mol. Genet. 15 (13) : 2106 ~ 2113
4. [학술지(정기간행물)] - Birnbaumer, L. / 2003 / A comparison of the genes coding for canonical TRP channels and their M, V and P relatives / Cell Calcium 33 (5-6) : 419 ~ 432
5. [학술지(정기간행물)] - Clapham, D.E. / 2003 / TRP channels as cellular sensors / Nature 426 (6966) : 517 ~ 524
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UCI(KEPA) : I410-ECN-0101-2012-510-003862902