지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.12
- 수록면
- 363 - 368 (6page)
이용수
초록· 키워드
오류제보하기
Allergies are immediate hypersensitive responses to antigens and interleukin (IL)-4 is involved in the initiation and development of allergic responses. Rb₁ has been known to have a variety of biological activities including anti-inflammatory activity, but the effect of Rb₁ on allergic responses is not known yet. The present study was undertaken to examine whether Rb₁ has an inhibitory effect on allergic response in mouse model. In allergic mouse model, our results showed that topical application of Rb₁ on atopic dermatitis (AD)-like skin lesions improved skin condition and inhibited starching behaviors. In addition, Rb₁ application not only suppressed mRNA expression of IL-4 and IL-10, but also prevented the nuclear factor of activated T cells 1 transcription. Moreover, Rb₁ application suppressed IL-4’ secretion. Taken together, these results suggest that Rb₁ has a potent inhibitory effect in AD-related T cell cytokine production and may be a candidate for therapeutic agent in allergy.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (23)
참고문헌 신청
Joo SS / 2009 / Suppression of T cell activation by hirsutenone, isolated from the bark of Alnus japonica, and its therapeutic advantages for atopic dermatitis / Eur J Pharmacol 614:98~105
Furrie E / 2005 / Probiotics and allergy / Proc Nutr Soc 64:465~469
Maggi E / 1988 / Profiles of lymphokine activities and helper function for IgE in human T cell clones / Eur J Immunol 18:1045~1050
Mosmann TR / 1989 / TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties / Annu Rev Immunol 7:145~173
Romagnani S / 1991 / Type 1 T helper and type 2 T helper cells: functions, regulation and role in protection and disease / Int J Clin Lab Res 21:152~158
Furrie E / 2005 / Probiotics and allergy / Proc Nutr Soc 64:465~469
Maggi E / 1988 / Profiles of lymphokine activities and helper function for IgE in human T cell clones / Eur J Immunol 18:1045~1050
Mosmann TR / 1989 / TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties / Annu Rev Immunol 7:145~173
Romagnani S / 1991 / Type 1 T helper and type 2 T helper cells: functions, regulation and role in protection and disease / Int J Clin Lab Res 21:152~158
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UCI(KEPA) : I410-ECN-0101-2012-524-004168276