지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.3
- 수록면
- 37 - 41 (5page)
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초록· 키워드
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This study investigated the antioxidative action of Corni Fructus aqueous extract on kidneys of diabetic mice. The electron donating abilities of Corni Fructus aqueous extract and its antioxidant activities (XO, SOD, CAT, GST, eNOS) in kidneys of C57BL/6 or db/db mice were evaluated. For in vivo study, seven week-old male mice were divided into normal control group (NC, C57BL/6 mice), diabetic control group (DC, db/db mice) and Corni Fructus (500 ㎎/㎏/day for 8 weeks) treated diabetic group (DCF, db/db mice). The electron donating abilities of Corni Fructus aqueous extract exhibited 7%, 24.4%, and 42.7% at concentrations of 100, 500, and 1000 ㎍/㎖, respectively. The activity of XO in the DCF group was significantly lower than the DC group by 35% (p ＜ 0.05). The SOD activity was significantly higher in the DCF group than the DC group by 26% (p ＜ 0.05). The activities of CAT and GST were lowered in the DCF group than the DC group by 26% (p ＜ 0.05) and 7.6%, respectively. The mRNA expression of eNOS in kidneys was lower in the DCF group than the DC group by 24%. These results indicate that Corni Fructus reduced oxidation stress as evidenced by the restoration of the enzymatic antioxidative defense system in renal tissues of db/db mice. It is suggested that these antioxidative actions of Corni Fructus on renal tissues in db/db mice could contribute to its renoprotective effects on diabetic nephropathy.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (26)
참고문헌 신청
Aebi,H / 1984 / Catalase in vitro / Methods Enzymol 105:121~126
Baynes,J.W / 1991 / Role of oxidative stress in development ofcomplications in diabetes / Diabetes 40:405~412
Blois,M.S / 1958 / Antioxidant determination by the use of a stablefree radical / Nature 181:1199~1200
Butler, R. / 2000 / Allopurinol normalizes endothelial dysfunction in type2 diabetics with mild hypertension / Hypertension 35:746~751
Del Maestro,R.F / 1980 / An approach to free radicals in medicineand biology / Acta Physiol. Scand. Suppl 492:153~168
Baynes,J.W / 1991 / Role of oxidative stress in development ofcomplications in diabetes / Diabetes 40:405~412
Blois,M.S / 1958 / Antioxidant determination by the use of a stablefree radical / Nature 181:1199~1200
Butler, R. / 2000 / Allopurinol normalizes endothelial dysfunction in type2 diabetics with mild hypertension / Hypertension 35:746~751
Del Maestro,R.F / 1980 / An approach to free radicals in medicineand biology / Acta Physiol. Scand. Suppl 492:153~168
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UCI(KEPA) : I410-ECN-0101-2012-513-004366322