지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.6
- 수록면
- 85 - 93 (9page)
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초록· 키워드
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Selective estrogen receptor modulators (SERMs) are synthetic molecules which bind to estrogen receptors (ER) and can modulate its transcriptional capabilities in different ways in diverse estrogen target tissues. Tamoxifen, the prototypical SERM, is extensively used for targeted therapy of ER positive breast cancers. Unfortunately, the use of tamoxifen is associated with acquired resistance and some undesirable side effects. This study investigated the availability of the conventional SERMs on the TAM-resistance breast cancer cells. SERMs showed more effectiveness in MCF-7 cells than tamoxifen resistant cells, except toremifene and ospemifene. Especially, toremifene was more efficacious in tamoxifen resistant cells than MCF-7. Ospemifene had similar cytotoxic activity on the two types of breast cancers. The other SERMs used in this experiment didn’t inhibit efficiently the proliferation of tamoxifen resistant cells. These results support the possibility to usage of toremifene on tamoxifen resistant cancer. The effectiveness by toremifene on tamoxifen resistant cells might be different pathways from the apoptosis and the autophagy. Further study should be needed to elucidate the underlying mechanism of effect of toremifene on tamoxifen resistant cancer.
목차
INTRODUCTION
MATERIALS AND METHOD
RESULTS
DISCUSSION
ACKNOWLEDGEMENTS
REFERENCES
참고문헌 (35)
참고문헌 신청
Adamo, V. / 2007 / Overview andnew strategies in metastatic breast cancer (MBC) for treatmentof tamoxifen-resistant patients / Ann. Oncol 18(6):53~57
Berthou, F. / 1994 / Involvement of cytochrome P450 3Aenzyme family in the major metabolic pathways of toremifenein human liver microsomes / Biochem. Pharmacol 47:1883~1895
Avioli,L.V / 1999 / SERM drugs for the prevention of osteoporosis / Trends. Endocrinol. Metab 10:317~319
Chen, Y. / 2009 / Superoxide is themajor reactive oxygen species regulating autophagy / Cell DeathDiffer 16:1040~1052
Chen, Y. / 2010 / Methods fordetecting autophagy and determining autophagy-induced celldeath / Can. J. Physiol. Pharmacol 88:285~295
Berthou, F. / 1994 / Involvement of cytochrome P450 3Aenzyme family in the major metabolic pathways of toremifenein human liver microsomes / Biochem. Pharmacol 47:1883~1895
Avioli,L.V / 1999 / SERM drugs for the prevention of osteoporosis / Trends. Endocrinol. Metab 10:317~319
Chen, Y. / 2009 / Superoxide is themajor reactive oxygen species regulating autophagy / Cell DeathDiffer 16:1040~1052
Chen, Y. / 2010 / Methods fordetecting autophagy and determining autophagy-induced celldeath / Can. J. Physiol. Pharmacol 88:285~295
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UCI(KEPA) : I410-ECN-0101-2013-513-000636825