지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.6
- 수록면
- 85 - 90 (6page)
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초록· 키워드
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Inducible nitric oxide synthase (iNOS) is a main enzyme producing nitric oxide during inflammation and thus contributes to the initiation and development of inflammatory cardiovascular diseases such as atherosclerosis. Epigallocatechin-3-gallate (EGCG), the major catechin derived from green tea, has multiple beneficial effects for treating cardiovascular disease, but the effect of EGCG on the expression of vascular iNOS remains unknown. In this study, we investigated (i) whether EGCG inhibits the expression of vascular iNOS induced by angiotensin II in human umbilical vein endothelial cells and, if it does inhibit, (ii) mechanisms underlying the inhibition. Angiotensin II increased expression levels of vascular iNOS; EGCG counteracted this effect. EGCG increased the production of reactive oxygen species. Moreover, EGCG did not affect the production of reactive oxygen species induced by angiotensin II. These data suggest a novel mechanism whereby EGCG provides direct vascular benefits for treating inflammatory cardiovascular diseases.
목차
Materials and Methods
Results
Discussion
Acknowledgments
References
참고문헌 (41)
참고문헌 신청
Alderton WK / 2001 / Nitric oxide synthases: structure, function and inhibition / Biochem J 357:593~615
Stuehr DJ / 1987 / Induction of nitrite/nitrate synthesis in murine macrophages by BCG infection, lymphokines, or interferon-γ / J Immunol 139:518~525
Liu VW / 2008 / Cardiovascular roles of nitric oxide: A review of insights from nitric oxide synthase gene disrupted mice / Cardiovasc Res 77:19~29
Kuhlencordt PJ / 2001 / Genetic deficiency of inducible nitric oxide synthase reduces atherosclerosis and lowers plasma lipid peroxides in apolipoprotein E-knockout mice / Circulation 103:3099~3104
Sánchez-Lemus E / 2009 / Angiotensin II AT1 blockade reduces the lipopolysaccharide-induced innate immune response in rat spleen / Am J Physiol Regul Integr Comp Physiol 296(5):1376~1384
Stuehr DJ / 1987 / Induction of nitrite/nitrate synthesis in murine macrophages by BCG infection, lymphokines, or interferon-γ / J Immunol 139:518~525
Liu VW / 2008 / Cardiovascular roles of nitric oxide: A review of insights from nitric oxide synthase gene disrupted mice / Cardiovasc Res 77:19~29
Kuhlencordt PJ / 2001 / Genetic deficiency of inducible nitric oxide synthase reduces atherosclerosis and lowers plasma lipid peroxides in apolipoprotein E-knockout mice / Circulation 103:3099~3104
Sánchez-Lemus E / 2009 / Angiotensin II AT1 blockade reduces the lipopolysaccharide-induced innate immune response in rat spleen / Am J Physiol Regul Integr Comp Physiol 296(5):1376~1384
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UCI(KEPA) : I410-ECN-0101-2013-510-000557288