지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.6
- 수록면
- 91 - 98 (8page)
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초록· 키워드
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Streptococcus pneumoniae is a major pathogen that causes various diseases, including pneumonia and sepsis, as millions of people suffer from S. pneumoniae infection worldwide. To better understand the immune and inflammatory responses to S. pneumoniae, we produced murine models. To investigate the differences between intranasal and intratracheal infection, BALB/c mice were infected with S. pneumoniae D39 intranasally or intratracheally. Mice showed no significant differences in survival rates, body weight changes, and bacterial loads. To investigate resistance and susceptibility among mouse strains, BALB/c, C57BL/6J, tumor necrosis factor-α (TNF-α) knockout, and interleukin-10 (IL-10) knockout mice were infected with S. pneumoniae D39 via intranasal or intravenous routes. In this study, BALB/c and C57BL/6J mice were resistant, IL-10 knockout mice were intermediate, and TNF-α knokout mice were susceptible to S. pneumoniae infection. These data show that intranasal and intratracheal infection induced similar results after S. pneumoniae infection, and the genetic background of mice must be considered when studying S. pneumoniae infection in vivo.
목차
Materials and Methods
Results
Discussion
Acknowledgments
References
참고문헌 (21)
참고문헌 신청
Kadioglu A / 2004 / The innate immune response to pneumococcal lung infection: the untold story / Trends Immunol 25(3):143~149
O'Brien KL / 2009 / Burden of disease caused by Streptococcus pneumoniae in children younger than 5 years: global estimates / Lancet 374(9693):893~902
Finkelstein JA / 2003 / Antibiotic-resistant Streptococcus pneumoniae in the heptavalent pneumococcal conjugate vaccine era: predictors of carriage in a multicommunity sample / Pediatrics 112(4):862~869
Huang SS / 2009 / Continued impact of pneumococcal conjugate vaccine on carriage in young children / Pediatrics 124(1):1~11
Liñares J / 2010 / Changes in antimicrobial resistance, serotypes and genotypes in Streptococcus pneumoniae over a 30-year period / Clin Microbiol Infect 16(5):402~410
O'Brien KL / 2009 / Burden of disease caused by Streptococcus pneumoniae in children younger than 5 years: global estimates / Lancet 374(9693):893~902
Finkelstein JA / 2003 / Antibiotic-resistant Streptococcus pneumoniae in the heptavalent pneumococcal conjugate vaccine era: predictors of carriage in a multicommunity sample / Pediatrics 112(4):862~869
Huang SS / 2009 / Continued impact of pneumococcal conjugate vaccine on carriage in young children / Pediatrics 124(1):1~11
Liñares J / 2010 / Changes in antimicrobial resistance, serotypes and genotypes in Streptococcus pneumoniae over a 30-year period / Clin Microbiol Infect 16(5):402~410
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UCI(KEPA) : I410-ECN-0101-2013-510-000557293