지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.6
- 수록면
- 147 - 152 (6page)
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초록· 키워드
오류제보하기
The cancer stem cell (CSC) hypothesis proposes that CSCs are responsible for metastasis and disease recurrence. Therefore, targeting CSCs has the potential to significantly improve outcomes for cancer patients. The OCT4 transcription factor gene is a master gene that plays a key role in the self-renewal and pluripotency of stem cells. In this study, we introduced an OCT4 reporting vector into 4T1 mouse breast cancer cells and sorted OCT4 high and OCT4 low cell populations. We then determined whether OCT4 expression is associated with maintenance and expansion of CSCs. We found that OCT4high 4T1 cells have an increased ability to form tumorsphere and a high expression of stem cell markers such as Sca-1, CD133, CD34, and ALDH1, when compared with OCT4<SUP>low</SUP> 4T1 cells. In addition, OCT4<SUP>high</SUP> 4T1 cells have greater tumorigenic potential in vivo. These findings suggest that OCT4 expression may be a useful target for stem cell-specific cancer therapy.
목차
Materials and Methods
Results
Discussion
Acknowledgment
References
참고문헌 (25)
참고문헌 신청
Dean M / 2005 / Tumour stem cells and drug resistance / Nat Rev Cancer 5(4):275~284
Charafe-Jauffret E / 2008 / Cancer Stem Cells in Breast: Current Opinion and Future Challenges / Pathobiology 75(2):75~84
Gangemi R / 2009 / Cancer stem cells: a new paradigm for understanding tumor growth and progression and drug resistance / Curr Med Chem 16(14):1688~1703
Hansis C / 2000 / Oct-4 expression in inner cell mass and trophectoderm of human blastocysts / Mol Hum Reprod 6(11):999~1004
Burdon T / 2002 / Signalling, cell cycle and pluripotency in embryonic stem cells / Trends Cell Biol 12(9):432~438
Charafe-Jauffret E / 2008 / Cancer Stem Cells in Breast: Current Opinion and Future Challenges / Pathobiology 75(2):75~84
Gangemi R / 2009 / Cancer stem cells: a new paradigm for understanding tumor growth and progression and drug resistance / Curr Med Chem 16(14):1688~1703
Hansis C / 2000 / Oct-4 expression in inner cell mass and trophectoderm of human blastocysts / Mol Hum Reprod 6(11):999~1004
Burdon T / 2002 / Signalling, cell cycle and pluripotency in embryonic stem cells / Trends Cell Biol 12(9):432~438
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UCI(KEPA) : I410-ECN-0101-2013-510-000557364