지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.6
- 수록면
- 161 - 169 (9page)
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초록· 키워드
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Gomisin A possesses a hepatic function-facilitating property in liver-injured rats. Its preventive action on carbon tetrachloride-induced cholestasis is due to maintenance of the function of the bile acidsindependent fraction. To investigate alterations in gene expression after gomisin A treatment on injured rat liver, DNA microarray analyses were performed on a Rat 44K 4-Plex Gene Expression platform with duplicated reactions after gomisin A treatment. We identified 255 up-regulated and 230 down-regulated genes due to the effects of gomisin A on recovery of carbon tetrachloride-induced rat liver damage. For functional characterization of these genes, Gene Ontology and Kyoto Encyclopedia of Genes and Genomes biochemical pathways analyses were performed. Many up-regulated or down-regulated genes were related to cell cycle or focal adhesion and cell death genes, respectively. Our microarray experiment indicated that the liver repair mechanism induced by gomisin A was strongly associated with increased gene expressions related to cell cycle and suppression of the gene expression related in cell death.
목차
Materials and Methods
Results and Discussion
Acknowledgment
References
참고문헌 (43)
참고문헌 신청
Liu GT / 1988 / Biochemical and pharmacologic effects of wuweizi [Schizandra chinensis (Turcz.) Baill.] and its chemical contents on animal livers / Sheng Li Ke Xue Jin Zhan 19(3):197~203
Suprunov NI / 1972 / Determination and study of lignan distribution in the fruits of Schisandra chinensis (Turcz.) Baill / Farmatsiia 21(3):34~37
Bao TT / 1980 / A comparison of the pharmacologic actions of 7 constituents isolated from Fructus schizandrae / Chin Med J 93(1):41~47
Maeda S / 1985 / Effects of gomisin A on liver functions in hepatotoxic chemicals-related rats / Jpn J Pharmacol 38(4):347~353
Yamada S / 1993 / Preventive effect of gomisin A, a lignan component of shizandra fruits, on acetaminophen-induced hepatotoxicity in rats / Biochem Pharmacol 46(6):1081~1085
Suprunov NI / 1972 / Determination and study of lignan distribution in the fruits of Schisandra chinensis (Turcz.) Baill / Farmatsiia 21(3):34~37
Bao TT / 1980 / A comparison of the pharmacologic actions of 7 constituents isolated from Fructus schizandrae / Chin Med J 93(1):41~47
Maeda S / 1985 / Effects of gomisin A on liver functions in hepatotoxic chemicals-related rats / Jpn J Pharmacol 38(4):347~353
Yamada S / 1993 / Preventive effect of gomisin A, a lignan component of shizandra fruits, on acetaminophen-induced hepatotoxicity in rats / Biochem Pharmacol 46(6):1081~1085
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UCI(KEPA) : I410-ECN-0101-2013-510-000557384