In this study, three-dimensional transient numerical simulations were carried out for a paint drying system of vehicle. The vehicle on assembly line passes through the drying system consisting of hot and cool air blow region. For the moving motion of the vehicle, moving of inlet boundary condition and MRF technique are used. The transient distribution of temperature and velocity in the drying system were predicted numerically. In order to validate the numerical results, transient distribution of the vehicle surface temperature was compared with experimental data, showing a good agreement. As a result of present study, optimal operating condition of the drying system are to be suggested.