지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.6
- 수록면
- 250 - 255 (6page)
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초록· 키워드
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Polycystic ovarian syndrome (PCOS) is a very common endocrine disorder in women of reproductive age. Nerve growth factor (NGF) may be involved in the pathogenesis of PCOS. In this study, we investigated the effect of Korean red ginseng extract (KRGE) on the ovarian morphology and NGF expression in an estradiol valerate (EV)-induced rat model. Polycystic ovaries were induced by a single intramuscular injection of estadiol valerate (4 mg, dissolved in sesame oil) in adult cycling rats. KRGE was administered orally (200 ㎎/㎏ body weight/day) for 60 consecutive days, beginning 60 days after the induction. Ovarian morphology was almost normalized and NGF was normalized in the EV+KRGE group. KRGE lowered the high numbers of antral follicles and increased the number of corpora lutea in the polycystic ovaries. The results are consistent with a beneficial effect of KRGE in the treatment of PCOS.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
ACKNOWLEDGEMENTS
REFERENCES
참고문헌 (29)
참고문헌 신청
1. [학술지(정기간행물)] - Azziz R / 2009 / The Androgen Excess and PCOS Society criteria for the polycystic ovary syndrome: the complete task force report / Fertil Steril 91 : 456 ~ 488
2. [학술지(정기간행물)] - Goodarzi MO / 2011 / Polycystic ovary syndrome: etiology, pathogenesis and diagnosis / Nat Rev Endocrinol 7 : 219 ~ 231
3. [학술지(정기간행물)] - Dumesic DA / 2008 / Polycystic ovary syndrome and oocyte developmental competence / Obstet Gynecol Surv 63 : 39 ~ 48
4. [학술지(정기간행물)] - Juengel JL / 2005 / The role of proteins of the transforming growth factor-beta superfamily in the intraovarian regulation of follicular development / Hum Reprod Update 11 : 143 ~ 160
5. [학술지(정기간행물)] - Azziz R / 2003 / Androgen excess is the key element in polycystic ovary syndrome / Fertil Steril 80 : 252 ~ 254
2. [학술지(정기간행물)] - Goodarzi MO / 2011 / Polycystic ovary syndrome: etiology, pathogenesis and diagnosis / Nat Rev Endocrinol 7 : 219 ~ 231
3. [학술지(정기간행물)] - Dumesic DA / 2008 / Polycystic ovary syndrome and oocyte developmental competence / Obstet Gynecol Surv 63 : 39 ~ 48
4. [학술지(정기간행물)] - Juengel JL / 2005 / The role of proteins of the transforming growth factor-beta superfamily in the intraovarian regulation of follicular development / Hum Reprod Update 11 : 143 ~ 160
5. [학술지(정기간행물)] - Azziz R / 2003 / Androgen excess is the key element in polycystic ovary syndrome / Fertil Steril 80 : 252 ~ 254
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