지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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초록· 키워드
오류제보하기
Objectives : This study was designed to investigate the clinical characteristics, relationship with antidepressants and incidence of restless legs syndrome(RLS) in depressed outpatients.
Methods : Total 160 adult patients(male 32, female 128) of psychiatric outpatient were enrolled in this study. We use the diagnostic criteria of International RLS Study Group(IRLSSG) for RLS. Also WHO quality of life scale abbreviated version(WHOQOL-BREF), Hamilton Depression Rating Scale-17(HAM-D) and Pittsburgh Sleep Quality Index(PSQI) was used to investigate the relationship between RLS and depression severity, quality of life, sleep quality.
Results : In 39(24.4%) out of the total 160 patients were diagnosed as having RLS. Among those 39 RLS patient, 19 patients(48.7%) was reported to have developed their RLS after starting depression treatment. The RLS group showed higher PSQI and HAM-D scores(p=0.02, p＜0.01) and lower WHOQOL-BREF score(p=0.06) compared to those of non-RLS. Compared to those of non-RLS group, the bupropion group showed a significantly low rate of RLS group (p=0.043) and the venlafaxine group showed a significantly high rate of RLS group(p=0.018). HAM-D score 7 or more group caused RLS 4.5 times compared those of less than HAM-D score 7 group.
Conclusion : In this study, depressed outpatients showed high incidence rate of RLS and RLS had influence on sleep quality, depression severity and quality of life. Moreover, certain antidepressants had potential to induce RLS. Therefore, these results suggest that appropriate treatment for depression is required to clinicians and development of RLS from depressed patients should be carefully monitored. Further research about the relationship between antidepressant and RLS is also necessary.
Methods : Total 160 adult patients(male 32, female 128) of psychiatric outpatient were enrolled in this study. We use the diagnostic criteria of International RLS Study Group(IRLSSG) for RLS. Also WHO quality of life scale abbreviated version(WHOQOL-BREF), Hamilton Depression Rating Scale-17(HAM-D) and Pittsburgh Sleep Quality Index(PSQI) was used to investigate the relationship between RLS and depression severity, quality of life, sleep quality.
Results : In 39(24.4%) out of the total 160 patients were diagnosed as having RLS. Among those 39 RLS patient, 19 patients(48.7%) was reported to have developed their RLS after starting depression treatment. The RLS group showed higher PSQI and HAM-D scores(p=0.02, p＜0.01) and lower WHOQOL-BREF score(p=0.06) compared to those of non-RLS. Compared to those of non-RLS group, the bupropion group showed a significantly low rate of RLS group (p=0.043) and the venlafaxine group showed a significantly high rate of RLS group(p=0.018). HAM-D score 7 or more group caused RLS 4.5 times compared those of less than HAM-D score 7 group.
Conclusion : In this study, depressed outpatients showed high incidence rate of RLS and RLS had influence on sleep quality, depression severity and quality of life. Moreover, certain antidepressants had potential to induce RLS. Therefore, these results suggest that appropriate treatment for depression is required to clinicians and development of RLS from depressed patients should be carefully monitored. Further research about the relationship between antidepressant and RLS is also necessary.
목차
서론
연구대상 및 방법
결과
고찰
결론
참고문헌
참고문헌 (43)
참고문헌 신청
Ekbom K / 1945 / Restless legs / Acta Med Scand 158:1~123
Allen RP / 2003 / Restless legs syndrome:diagnostic criteria,special considerations,and epidemiology,A report from the restless legs syndrome diagnosis and epidemiology workshop at the National Institutes of Health / Sleep Med 4:101~119
Yun CH / 2006 / Pathophysiology of the restless legs syndrome:dopamine and iron / J Kor Sleep Soc 3:22~28
Ondo W / 1996 / Restless legs syndrome:clinicoetiologic correlates / Neurology 47:1435~1441
Rutkove SB / 1996 / Restless legs syndrome in patients with polyneuropathy / Muscle Nerve 19:670~672
Allen RP / 2003 / Restless legs syndrome:diagnostic criteria,special considerations,and epidemiology,A report from the restless legs syndrome diagnosis and epidemiology workshop at the National Institutes of Health / Sleep Med 4:101~119
Yun CH / 2006 / Pathophysiology of the restless legs syndrome:dopamine and iron / J Kor Sleep Soc 3:22~28
Ondo W / 1996 / Restless legs syndrome:clinicoetiologic correlates / Neurology 47:1435~1441
Rutkove SB / 1996 / Restless legs syndrome in patients with polyneuropathy / Muscle Nerve 19:670~672
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UCI(KEPA) : I410-ECN-0101-2013-513-000477997