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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.6
- 수록면
- 1,551 - 1,561 (11page)
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The present study was performed to investigate the effect of endurance running on muscle protein synthesis. Male Sprague-Dawley rats(n = 49) were randomly assigned to the time course of the treadmill running (VO₂max 75-80%, 1hr). Muscle samples were obtained before and recovery period of the exercise (immediately, 30 min, 1hr, 2hr, 3hr and 6hr from the running) at the soleus muscle for the determination of mammalian target of rapamycin (mTOR), p70S6 kinase (p70S6k), eukaryotic initiation factor (eIF) 4E-binding protein (4E-BP1) and AMPK phosphorylation. Endurance exercise generated a significant increase in mTOR phosphorylation immediately after exercise and the phosphorylation maintained up to 6hr of recovery (∼90%, p=.024). In addition, 4EBP1 phosphorylation was significantly increased at the immediately after exercise and decreased up to an hour recovery. However, 4EBP1 was resumed to increase for 2-3hrs during recovery (∼48%, p=.05). However, Phosphorylation of p70S6K was elevated above rest level throughout the 6hrs recovery and reached peak at 6hr recovery (303%, p=.001). On the other hand, Phospho-AMPK (Thr172) was increased from 30min to 3hr of recovery (p＜.05). These results clearly demonstrate that intensitive endurance running result in significant differences in protein signaling of muscle protein synthesis.
목차
Abstract
Ⅰ. 서론
Ⅱ. 연구방법
Ⅲ. 결과
Ⅳ. 논의
Ⅴ. 결론
참고문헌
참고문헌 (30)
참고문헌 신청
1. [단행본] - Astrand, P. O. / 1986 / Textbook of Work Physiology
2. [학술지(정기간행물)] - Beugnet, A. / 2003 / Target of rapamycin (TOR) -signaling and RAIP motifs play distinct roles in the mammalian TOR-dependent phosphorylation of initiation factor 4E-binding protein 1 / J Biol Chem 278 : 40717 ~ 40722
3. [학술지(정기간행물)] - Bodine, S. C. / 2001 / Akt/mTOR pathway is a crucial regulator of skeletal muscle hypertrophy and can prevent muscle atrophy in vivo / Nat Cell Biol 3 : 1014 ~ 1049
4. [학술지(정기간행물)] - Bolster, D, R. / 2003 / Immediate response of mammalian target of rapamycin (mTOR)-mediated signalling following acute resistance exercise in rat skeletal muscle / J Physiol 553 (Pt 1) : 1 ~
5. [학술지(정기간행물)] - Burnett, P. E. / 1998 / RAFT1 phosphorylation of the translational regulators p70S6 kinase and 4E-BP1 / Proc Natl Acad Sci 95 : 1432 ~ 1437
2. [학술지(정기간행물)] - Beugnet, A. / 2003 / Target of rapamycin (TOR) -signaling and RAIP motifs play distinct roles in the mammalian TOR-dependent phosphorylation of initiation factor 4E-binding protein 1 / J Biol Chem 278 : 40717 ~ 40722
3. [학술지(정기간행물)] - Bodine, S. C. / 2001 / Akt/mTOR pathway is a crucial regulator of skeletal muscle hypertrophy and can prevent muscle atrophy in vivo / Nat Cell Biol 3 : 1014 ~ 1049
4. [학술지(정기간행물)] - Bolster, D, R. / 2003 / Immediate response of mammalian target of rapamycin (mTOR)-mediated signalling following acute resistance exercise in rat skeletal muscle / J Physiol 553 (Pt 1) : 1 ~
5. [학술지(정기간행물)] - Burnett, P. E. / 1998 / RAFT1 phosphorylation of the translational regulators p70S6 kinase and 4E-BP1 / Proc Natl Acad Sci 95 : 1432 ~ 1437
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UCI(KEPA) : I410-ECN-0101-2013-692-000489686