지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.6
- 수록면
- 313 - 321 (9page)
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Exercise has a lot of beneficial potentials in normal health, anti-aging, and neurodegenerative diseases. To investigate whether exercise has beneficial effects on Parkinson's disease (PD), we used a genetic LRRK2 (leucine-rich repeat kinase) Drosophila model for Parkinsonism. Mutations in LRRK2 gene cause late-onset autosomal dominant PD and contribute to sporadic PD as well. In the present study, we set up two exercise programs for the G2019S-LRRK2 transgenic flies that were designed to mimic human exercise programs: low and high intensity. Fly climbing assays were conducted and monitored to represent the locomotor activity (movement ability). For low intensity exercise program, the day 1 adult flies exercised in a 5 inch cylinder for 30 minute, three days per week for a total of three weeks. For the high intensity exercise program, the day 1 adult flies exercised in a 10 inch cylinder f 30 minute daily for three weeks. The expression level of G2019S-LRRK2 in fly brain homogenates were significantly decreased in the low intensity exercise group compared with no exercise control transgenic flies. In contrast, the expression levels of G2019S-LRRK2 flies in the high intensity exercise group were increased compared with the no exercise control flies. Currently, we are investigating the mechanisms underlying exercise altering LRRK2 expression levels. These studies may provide new insight into the relationship between exercise and PD, and may provide the potential non-pharmacological strategies for PD treatment.
목차
Abstract
1. 서론
2. 연구 방법
3. 결과 및 해석
4. 결론
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인용문헌
참고문헌 (49)
참고문헌 신청
1. [학술지(정기간행물)] - Adams, A. K / 2002 / The role of antioxidants in exercise and disease prevention / Phys. Sports Med 30 (5) : 37 ~ 44
2. [학술지(정기간행물)] - Archer, T / 2011 / Exercise alleviates Parkinsonism: clinical and laboratory evidence / Acta Neurol. Scand 123 (2) : 73 ~ 84
3. [학술지(정기간행물)] - Asha Devi, S / 2009 / Aging brain: prevention of oxidative stress by vitamin E and exercise / Scientific World- Journal 9 : 366 ~ 372
4. [학술지(정기간행물)] - Beavers, K. M / 2010 / Effect of exercise training on chronic inflammation / Clin. Chim. Acta 411 (11) : 785 ~ 793
5. [학술지(정기간행물)] - Birkmayer, W / 1962 / The L-dihydroxyphenylalanine (L-DOPA) effect in Parkinson's syndrome in man: On the pathogenesis and treatment of Parkinson akinesis / Arch Psychiatr Nervenkr Z Gesamte Neurol Psychiatr 203 : 560 ~ 574
2. [학술지(정기간행물)] - Archer, T / 2011 / Exercise alleviates Parkinsonism: clinical and laboratory evidence / Acta Neurol. Scand 123 (2) : 73 ~ 84
3. [학술지(정기간행물)] - Asha Devi, S / 2009 / Aging brain: prevention of oxidative stress by vitamin E and exercise / Scientific World- Journal 9 : 366 ~ 372
4. [학술지(정기간행물)] - Beavers, K. M / 2010 / Effect of exercise training on chronic inflammation / Clin. Chim. Acta 411 (11) : 785 ~ 793
5. [학술지(정기간행물)] - Birkmayer, W / 1962 / The L-dihydroxyphenylalanine (L-DOPA) effect in Parkinson's syndrome in man: On the pathogenesis and treatment of Parkinson akinesis / Arch Psychiatr Nervenkr Z Gesamte Neurol Psychiatr 203 : 560 ~ 574
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UCI(KEPA) : I410-ECN-0101-2013-590-000502407