지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.9
- 수록면
- 153 - 160 (8page)
이용수
초록· 키워드
오류제보하기
To evaluate the whitening effect of black tea water extract (BT), BT was topically applied to artificially hyperpigmented spots on the back skins of brown guinea-pigs (weight: 450~500 g) induced by 1,500 mJ/㎠ of ultraviolet B (UVB) irradiation. The test compounds of 30 ㎕ were applied twice a day, six days a week, for four weeks. The artificially hyperpigmented spots were divided into 5 groups: control (UVB + saline, C), vehicle control [UVB + propylene glycol: ethanol: water (5 : 3 : 2), VC], positive control (UVB + 2% hydroquinone, PC), experimental 1 (UVB + 1% BT), experimental 2 (UVB + 2% BT). After 4-week application, the spots were removed by biopsy punch under anesthetic condition and used as specimens for the histological examination. The total polyphenol and flavonoid contents of BT were 104 and 91 ㎎/g, respectively. The electron-donating ability of BT revealed a dose-dependent response, showing the excellent capacities of 86% at 800 ㎍/㎖. The artificially hyperpigmented spots treated with the PC and BT were obviously lightened compared to the C and VC groups. At the fourth week, the melanin indices for the PC and BT groups were significantly lower (p ＜ 0.00l) than those of the C and VC groups. In histological examination, PC and BT groups were significantly reduced in the melanin pigmentation, the proliferation of melanocytes and the synthesis of melanosomes compared to the C and VC groups. It is found that BT inhibits the proliferation of melanocytes and synthesis of melanosomes in vivo using brown guinea pigs, thereby showing a definite skin whitening effect.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSIONS
REFERENCES
참고문헌 (30)
참고문헌 신청
Ammar, R.B. / 2009 / Antioxidant and free radical-scavenging properties ofthree flavonoids isolated from the leaves of Rhamnus alaternusL. (Rhamnaceae): a structure-activity relationship study / FoodChemistry 116:258~264
Aoki, Y. / 2007 / Melanogenesisinhibition by an Oolong tea extract in B16 mouse melanomacells and UV-induced skin pigmentation in brownishguinea pigs / Biosci. Biotechnol. Biochem 71:1879~1885
Balentine, D.A. / 1997 / Thechemistry of tea flavonoids / Crit. Rev. Food Sci. Nutr 37:693~704
Bolognia, J.L. / 1990 / Hairlesspigmented guinea pigs: a new model for the study of mammalianpigmentation / Pigment Cell Res 3:150~156
Briganti, S. / 2003 / Chemical andinstrumental approaches to treat hyperpigmentation / PigmentCell Res 16:101~110
Aoki, Y. / 2007 / Melanogenesisinhibition by an Oolong tea extract in B16 mouse melanomacells and UV-induced skin pigmentation in brownishguinea pigs / Biosci. Biotechnol. Biochem 71:1879~1885
Balentine, D.A. / 1997 / Thechemistry of tea flavonoids / Crit. Rev. Food Sci. Nutr 37:693~704
Bolognia, J.L. / 1990 / Hairlesspigmented guinea pigs: a new model for the study of mammalianpigmentation / Pigment Cell Res 3:150~156
Briganti, S. / 2003 / Chemical andinstrumental approaches to treat hyperpigmentation / PigmentCell Res 16:101~110
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UCI(KEPA) : I410-ECN-0101-2013-513-000310517