지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국산업응용수학회 JOURNAL OF THE KOREAN SOCIETY FOR INDUSTRIAL AND APPLIED MATHEMATICS Journal of the Korean Society for Industrial and Applied Mathematics Vol.15 No.3
- 발행연도
- 2011.8
- 수록면
- 191 - 199 (9page)
이용수
초록· 키워드
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In this paper, we adopt a position specific scoring matrix as an abstraction of amino acid type to derive two new statistical potentials for protein structure prediction, and investigated its effect on the quality of the potentials compared to that derived using residue specific amino acid identity. For stringent test of the potential quality, we carried out folding simulations of 91 residue A chain of protein 2gpi, and found unexpectedly that the abstract amino acid type improved the quality of the one-body type statistical potential, but not for the two-body type statistical potential which describes long range interactions. This observation could be effectively used when one develops more accurate potentials for structure prediction, which are usually involved in merging various one-body and many-body potentials.
목차
ABSTRACT
1. INTRODUCTION
2. TWO NEW STATISTICAL POTENTIALS FOR PROFILE CONTACT
3. NUMERICAL SIMULATION
4. RESULTS
5. DISCUSSION
ACKNOWLEDGMENTS
REFERENCES
참고문헌 (18)
참고문헌 신청
A. Neumaier / 1997 / Molecular modeling of proteins and mathematical prediction of protein structure / SIAM Rev 39:407~460
C.B. Anfinsen / 1973 / Principles that govern the folding of protein chains / Science 181:223~230
R. Samudrala / 1998 / An all-atom distance-dependent conditional probability discriminatory function for protein structure prediction / J Mol Biol 275:895~916
M.J. Sippl / 1990 / Calculation of conformational ensembles from potentials of mean force. An approach to the knowledge-based prediction of local structures in globular proteins / J Mol Biol 213:859~883
H. Zhou / 2002 / Distance-scaled, finite ideal-gas reference state improves structure-derived potentials of mean force for structure selection and stability prediction / Protein science 11:2714~2726
C.B. Anfinsen / 1973 / Principles that govern the folding of protein chains / Science 181:223~230
R. Samudrala / 1998 / An all-atom distance-dependent conditional probability discriminatory function for protein structure prediction / J Mol Biol 275:895~916
M.J. Sippl / 1990 / Calculation of conformational ensembles from potentials of mean force. An approach to the knowledge-based prediction of local structures in globular proteins / J Mol Biol 213:859~883
H. Zhou / 2002 / Distance-scaled, finite ideal-gas reference state improves structure-derived potentials of mean force for structure selection and stability prediction / Protein science 11:2714~2726
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UCI(KEPA) : I410-ECN-0101-2013-410-000693213