지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.9
- 수록면
- 261 - 271 (11page)
이용수
초록· 키워드
오류제보하기
Chemical radiation protection is an important strategy to protect living beings against the deleterious effects of radiation. In the present study, the radioprotective effect of hydro-alcoholic extract of Panax ginseng extract (PGR-HAE) was studied on radiation-induced deleterious alterations in Swiss albino mice. Oral administration of such extract (25 mg/kg b wt/day/animal) for 5 consecutive days, half an h. before whole-body exposure to 6 Gy gamma radiation, enhanced the 30 days survival and also inhibited the radiogenic sickness, weight loss and life shortening. PGR-HAE ameliorated radiation induced depletion in blood constituents at different necropsy intervals between 12 h to 30 d, and significantly increased the number of femoral spleen colony forming units that survived after irradiation. Furthermore, it checked depletion of glutathione and antioxidant enzymes (superoxide dismutase, catalase, and glutathione S-transferase) as well as elevation of lipid peroxidation (LPO) level in blood and liver. The significant reduction in the yield of LPO demonstrates that PGR-HAE protects the membranes against radiation-induced oxidative damage. These findings conclude that such plant extract provides significant radioprotection, and it may be potentially valuable in the prevention of injuries caused during planned and unplanned radiation exposure.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
ACKNOWLEDGEMENTS
REFERENCES
참고문헌 (68)
참고문헌 신청
1. [학술지(정기간행물)] - Ames BN / 1993 / Oxidants, antioxidants, and the degenerative diseases of aging / Proc Natl Acad Sci U S A 90 : 7915 ~ 7922
2. [학술지(정기간행물)] - LaVerne JA / 2000 / OH radicals and oxidizing products in the gamma radiolysis of water / Radiat Res 153 : 196 ~ 200
3. [학술지(정기간행물)] - Song JY / 2003 / Radioprotective effects of ginsan, an immunomodulator / RADIATION RESEARCH 159 : 768 ~ 774
4. [학술지(정기간행물)] - Arora R / 2005 / Radioprotection by plant products: present status and future prospects / Phytother Res 19 : 1 ~ 22
5. [학술지(정기간행물)] - Sankaranarayanan K / 1999 / Ionizing radiation and genetic risks. X. The potential “disease phenotypes” of radiation-induced genetic damage in humans: perspectives from human molecular biology and radiation genetics / Mutat Res 429 : 45 ~ 83
2. [학술지(정기간행물)] - LaVerne JA / 2000 / OH radicals and oxidizing products in the gamma radiolysis of water / Radiat Res 153 : 196 ~ 200
3. [학술지(정기간행물)] - Song JY / 2003 / Radioprotective effects of ginsan, an immunomodulator / RADIATION RESEARCH 159 : 768 ~ 774
4. [학술지(정기간행물)] - Arora R / 2005 / Radioprotection by plant products: present status and future prospects / Phytother Res 19 : 1 ~ 22
5. [학술지(정기간행물)] - Sankaranarayanan K / 1999 / Ionizing radiation and genetic risks. X. The potential “disease phenotypes” of radiation-induced genetic damage in humans: perspectives from human molecular biology and radiation genetics / Mutat Res 429 : 45 ~ 83
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UCI(KEPA) : I410-ECN-0101-2013-524-000762172