지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.9
- 수록면
- 315 - 324 (10page)
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초록· 키워드
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This study investigated the effect of red ginseng extract on metastasis of colon cancer cells in vitro and in vivo. Wound healing migration, cell motility, invasion, and activity, protein expression, and mRNA expression of matrix metalloproteinases (MMPs) were examined in SW480 human colon cancer cells. SW480 cells were cultured with or without 100 μg/L PMA in the absence or presence of various concentrations (100, 200, or 300 μg/mL) of red ginseng extract. Red ginseng extract treatment caused significant suppression of cell motility and invasion (p<0.05) in SW480 cells. Red ginseng extract inhibited MMP-2 and MMP-9 activity and their protein and mRNA expression in a dose-dependent manner (p<0.05) in SW480 cells. For experimental metastasis, BALB/c mice were injected intravenously with CT-26 mouse colon cancer cells in the tail vein, and were orally administered various concentrations (0, 75, 150, or 300 mg/kg body weight) of red ginseng extract for 3 weeks. Numbers of pulmonary nodules were signifi cantly decreased in mice that were fed red ginseng extract (p<0.05). Plasma MMP-2 and MMP-9 activity significantly decreased in response to treatment with red ginseng extract in mice (p<0.05). These data suggest that red ginseng extract may be useful for prevention of cancer invasion and metastasis through inhibition of MMP-2 and MMP-9 pathways.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
ACKNOWLEDGEMENTS
REFERENCES
참고문헌 (48)
참고문헌 신청
1. [학술지(정기간행물)] - Wang CZ / 2009 / The mitochondrial pathway is involved in American ginseng-induced apoptosis of SW- 480 colon cancer cells / Oncol Rep 21 : 577 ~ 584
2. [보고서] - Ministry of Health and Welfare / 2008 / Annual report of the central cancer registry in Korea
3. [학술지(정기간행물)] - Okegawa T / 2004 / The role of cell adhesion molecule in cancer progression and its application in cancer therapy / Acta Biochim Pol 51 : 445 ~ 457
4. [학술지(정기간행물)] - Pepper MS / 1996 / Angiogenesis: a paradigm for balanced extracellular proteolysis during cell migration and morphogenesis / Enzyme Protein 49 : 138 ~ 162
5. [학술지(정기간행물)] - Pepper MS / 2001 / Role of the matrix metalloproteinase and plasminogen activator-plasmin systems in angiogenesis / Arterioscler Thromb Vasc Biol 21 : 1104 ~ 1117
2. [보고서] - Ministry of Health and Welfare / 2008 / Annual report of the central cancer registry in Korea
3. [학술지(정기간행물)] - Okegawa T / 2004 / The role of cell adhesion molecule in cancer progression and its application in cancer therapy / Acta Biochim Pol 51 : 445 ~ 457
4. [학술지(정기간행물)] - Pepper MS / 1996 / Angiogenesis: a paradigm for balanced extracellular proteolysis during cell migration and morphogenesis / Enzyme Protein 49 : 138 ~ 162
5. [학술지(정기간행물)] - Pepper MS / 2001 / Role of the matrix metalloproteinase and plasminogen activator-plasmin systems in angiogenesis / Arterioscler Thromb Vasc Biol 21 : 1104 ~ 1117
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UCI(KEPA) : I410-ECN-0101-2013-524-000762238