지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.9
- 수록면
- 189 - 195 (7page)
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초록· 키워드
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Cyclooxygenase-2 (COX-2) is believed to be a multifunctional neural modulator that affects synaptic plasticity in the hippocampus. In the present study, we investigated the differential effects of treadmill exercise on COX-2 immunoreactivity in the dentate gyrus in early and chronic diabetic stages in Zucker diabetic fatty (ZDF) rats and lean control (ZLC) rats. To this end, ZLC and ZDF rats at 6 or 23 weeks of age were put on a treadmill with or without running for 1 h/day for 5 consecutive days at 16-22 m/min for 5 weeks or 12-16 m/min for 7 weeks, respectively. Treadmill exercise in prediabetic and chronic diabetic rats significantly reduced blood glucose levels. In particular, exercise in the prediabetic rat blocked the onset of diabetes. COX-2 immunoreactivity was mainly detected in the granule cell layer of the dentate gyrus and stratum pyramidale of the CA3 region in all groups. COX-2 immunoreactivity was significantly increased in these regions of ZLC and ZDF rats after treadmill exercise in the early diabetic stage. However, COX-2 immunoreactivity was not changed in these regions in ZDF rats after treadmill exercise in the chronic stage. These results suggest that treadmill exercise in diabetic animals in the chronic stage has limited ability to cause plasticity in the dentate gyrus.
목차
Materials and Methods
Results
Discussion
Acknowledgments
References
참고문헌 (46)
참고문헌 신청
Yamagata K / 1993 / Expression of a mitogen-inducible cyclooxygenase in brain neurons: regulation by synaptic activity and glucocorticoids / Neuron 11:371~386
Vane JR / 1998 / Cyclooxygenases 1 and 2 / Annu Rev Pharmacol Toxicol 38:97~120
Kaufmann WE / 1997 / Cyclooxygenases and the central nervous system / Prostaglandins 54:601~624
Yamashita A / 2007 / Hypothermic, but not normothermic, ischemia causes a drastic increase in cyclooxygenase-2 immunoreactive granule cells in rat dentate gyrus after 4 hours of ischemic reperfusion / Arch Histol Cytol 70:197~205
Kaufmann WE / 1996 / COX-2, a synaptically induced enzyme, is expressed by excitatory neurons at postsynaptic sites in rat cerebral cortex / Proc Natl Acad Sci USA 93:2317~2321
Vane JR / 1998 / Cyclooxygenases 1 and 2 / Annu Rev Pharmacol Toxicol 38:97~120
Kaufmann WE / 1997 / Cyclooxygenases and the central nervous system / Prostaglandins 54:601~624
Yamashita A / 2007 / Hypothermic, but not normothermic, ischemia causes a drastic increase in cyclooxygenase-2 immunoreactive granule cells in rat dentate gyrus after 4 hours of ischemic reperfusion / Arch Histol Cytol 70:197~205
Kaufmann WE / 1996 / COX-2, a synaptically induced enzyme, is expressed by excitatory neurons at postsynaptic sites in rat cerebral cortex / Proc Natl Acad Sci USA 93:2317~2321
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UCI(KEPA) : I410-ECN-0101-2013-510-000764410