지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.12
- 수록면
- 205 - 210 (6page)
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초록· 키워드
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Objectives：Hypothalamic-Pituitary-Adrenocortical(HPA) system dysregulation plays an important role in the pathophysiology of major depressive disorder. Medically unexplained somatic symptoms comprised the predominant complaints of korean patients with major depressive disorder. It might be related to dysregulation of HPA system and somatic symptoms. The aim of this study was to investigate the association between Hamilton Depression Rating Scale severity and the Plasma Adrenocorticotropic Hormone(ACTH) & Serum Cortisol level in Korean patients with major depressive disorder.
Methods：Our study design was prospective. A total 111 hospitalized patients with major depressive disorder (DSM-IV) at Anam Hospital, Korea University Medical Center between Jan 2009 and May 2011 were selected. Hamilton Depression Rating Scale was measured by psychiatrist. Plasma ACTH, Serum Cortisol levels were analyzed at the time of admission.
Results：There are significant correlations(p＜0.05) between Hamilton Depression Rating Scale of somatic component(HAM-D 11-15 item) and Plasma ACTH and Serum Cortisol level. However, other HAM-D sub items were not significantly correlated with Plasma ACTH and Serum Cortisol level except somatic component.
Conclusion：Our Study results suggest that hyperactivity of HPA axis might be correlation with somatic symptoms in korean patients with major depressive disorder.
Methods：Our study design was prospective. A total 111 hospitalized patients with major depressive disorder (DSM-IV) at Anam Hospital, Korea University Medical Center between Jan 2009 and May 2011 were selected. Hamilton Depression Rating Scale was measured by psychiatrist. Plasma ACTH, Serum Cortisol levels were analyzed at the time of admission.
Results：There are significant correlations(p＜0.05) between Hamilton Depression Rating Scale of somatic component(HAM-D 11-15 item) and Plasma ACTH and Serum Cortisol level. However, other HAM-D sub items were not significantly correlated with Plasma ACTH and Serum Cortisol level except somatic component.
Conclusion：Our Study results suggest that hyperactivity of HPA axis might be correlation with somatic symptoms in korean patients with major depressive disorder.
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대상 및 방법
결과
고찰
참고문헌
참고문헌 (24)
참고문헌 신청
1. [학술지(정기간행물)] - 박준혁 / 2011 / 한국의 우울증 역학에 대한 고찰 / 대한의사협회지 54 (4) : 362 ~ 369
2. [학술지(정기간행물)] - 고영훈 / 2005 / 정신병적 우울증의 특성과 치료 / 대한정신약물학회지 16 (5) : 341 ~ 350
3. [학술지(정기간행물)] - Burke HM / 2005 / Depression and cortisol responses to psychological stress; A meta-analysis / Psychoneuroendocrinology 30 : 846 ~ 856
4. [학술지(정기간행물)] - Connor TJ / 1998 / Depression,stress and immunological activation:the role of cytokines in depressive disorders / Life Sci 62 : 583 ~ 606
5. [학술지(정기간행물)] - Nemeroff CB / 1996 / The corticotropin-releasing factor(CRF)hypothesis of depression:new findings and new directions / Mol Psychiatry 1 : 336 ~ 342
2. [학술지(정기간행물)] - 고영훈 / 2005 / 정신병적 우울증의 특성과 치료 / 대한정신약물학회지 16 (5) : 341 ~ 350
3. [학술지(정기간행물)] - Burke HM / 2005 / Depression and cortisol responses to psychological stress; A meta-analysis / Psychoneuroendocrinology 30 : 846 ~ 856
4. [학술지(정기간행물)] - Connor TJ / 1998 / Depression,stress and immunological activation:the role of cytokines in depressive disorders / Life Sci 62 : 583 ~ 606
5. [학술지(정기간행물)] - Nemeroff CB / 1996 / The corticotropin-releasing factor(CRF)hypothesis of depression:new findings and new directions / Mol Psychiatry 1 : 336 ~ 342
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UCI(KEPA) : I410-ECN-0101-2013-513-001381669