지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.12
- 수록면
- 257 - 266 (10page)
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Objectives：The aims of this study were to examine changes of cognitive function and its characteristics, and to identify influencing factors on cognitive fuction in patients with thyroid disorders.
Methods：Data of 98 patients with thyroid disorders(16 males and 82 females) recruited from thyroid clinic in the Endocine Center of Kosin University Gospel Hospital were obtained by semi-structred interviews and MoCA-K(Korean Version of the Montreal Cognitive Assessment) and Korean version of the HDRS-17(Hamilton Depression Rating Scale-17).
Results：1) The cognitive dysfunction was seen in 24 patients with thyroid disorders(24.49%). The total scores of the MoCA-K tests in thyroid patients with cognitive dysfunction(18.42±3.75) were significantly(p＜0.001) lower than those of controls(26.43±2.01). Their subtest scores of the MoCA-K such as visuospatial/executive, naming, attention, language, abstraction, delayed recall were also lower than those of controls. 2) The thyroid patients with MoCA-K ≤22 showed higher age and onset age of thyroid disorders, and had lower education and HDL-cholesterol(p＜0.001 respectively). 3) Total scores of the MoCA-K tests in patients with thyroid disorders had positive correlation with education(ρ=0.583, p＜0.01), and had negative correlation with age(ρ=-0.462, p＜0.01) and onset age of thyroid disorders(ρ=-0.494, p＜0.01). Otherwise, triiodothyronine and HDL-cholesterol had positive correlation, and sex and triglyceride had negative correlation with some subtest scores of the MoCA-K.
Conclusions：The cognitive dysfunction accompanied in about 1/4 of patients with thyroid disorders. The finding that the cognitive function in thyroid disorders seemed to be mainly associated with age and onset age of thyroid disorders, suggested a possibility of an important role of aging mechanism.
Methods：Data of 98 patients with thyroid disorders(16 males and 82 females) recruited from thyroid clinic in the Endocine Center of Kosin University Gospel Hospital were obtained by semi-structred interviews and MoCA-K(Korean Version of the Montreal Cognitive Assessment) and Korean version of the HDRS-17(Hamilton Depression Rating Scale-17).
Results：1) The cognitive dysfunction was seen in 24 patients with thyroid disorders(24.49%). The total scores of the MoCA-K tests in thyroid patients with cognitive dysfunction(18.42±3.75) were significantly(p＜0.001) lower than those of controls(26.43±2.01). Their subtest scores of the MoCA-K such as visuospatial/executive, naming, attention, language, abstraction, delayed recall were also lower than those of controls. 2) The thyroid patients with MoCA-K ≤22 showed higher age and onset age of thyroid disorders, and had lower education and HDL-cholesterol(p＜0.001 respectively). 3) Total scores of the MoCA-K tests in patients with thyroid disorders had positive correlation with education(ρ=0.583, p＜0.01), and had negative correlation with age(ρ=-0.462, p＜0.01) and onset age of thyroid disorders(ρ=-0.494, p＜0.01). Otherwise, triiodothyronine and HDL-cholesterol had positive correlation, and sex and triglyceride had negative correlation with some subtest scores of the MoCA-K.
Conclusions：The cognitive dysfunction accompanied in about 1/4 of patients with thyroid disorders. The finding that the cognitive function in thyroid disorders seemed to be mainly associated with age and onset age of thyroid disorders, suggested a possibility of an important role of aging mechanism.
목차
서론
대상 및 방법
결과
고찰
결론
참고문헌
참고문헌 (45)
참고문헌 신청
1. [학술지(정기간행물)] - Dugbartey AT / 1998 / Neurocognitive aspects of hypothyroidism / Arch Internal Med 158 : 1413 ~ 1418
2. [학술지(정기간행물)] - Zhu DF / 2006 / fMRI revealed neural substrate for reversible working memory dysfunction in subclinical hypothyroidism / Brain 129 : 2923 ~ 2930
3. [학술지(정기간행물)] - Roberts LM / 2006 / Is subclinical thryoid dysfunction in the elderly associated with depression of cognitive dysfunction / Ann Intern Med 145 : 573 ~ 581
4. [학술지(정기간행물)] - Cooper DS / 2004 / Thyroid disease in the oldest old:the exception to the rule / JAMA 292 : 2651 ~ 2654
5. [학술지(정기간행물)] - Quinlan P / 2010 / Thyroid hormones are associated with poorer cognition in mild cognitive impairment / Dement Geriatr Cogn Disord 30 : 205 ~ 211
2. [학술지(정기간행물)] - Zhu DF / 2006 / fMRI revealed neural substrate for reversible working memory dysfunction in subclinical hypothyroidism / Brain 129 : 2923 ~ 2930
3. [학술지(정기간행물)] - Roberts LM / 2006 / Is subclinical thryoid dysfunction in the elderly associated with depression of cognitive dysfunction / Ann Intern Med 145 : 573 ~ 581
4. [학술지(정기간행물)] - Cooper DS / 2004 / Thyroid disease in the oldest old:the exception to the rule / JAMA 292 : 2651 ~ 2654
5. [학술지(정기간행물)] - Quinlan P / 2010 / Thyroid hormones are associated with poorer cognition in mild cognitive impairment / Dement Geriatr Cogn Disord 30 : 205 ~ 211
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UCI(KEPA) : I410-ECN-0101-2013-513-001381725