지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.12
- 수록면
- 387 - 396 (10page)
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초록· 키워드
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Objectives: To examine the associations between the urinary t, t-muconic acid (t, t-MA) concentration and three indices of insulin resistance; namely, the homeostasis assessment of insulin resistance (HOMAIR) index, blood insulin level and fasting glucose level.
Methods: A panel study was performed on the elderly at a public health care center population in the northern area of Seoul between 2008 and 2010. The participants were 560 elderly, over 60 years of age whose urinary t, t-MA and insulin resistance indices had been measured; questionnaires were completed by these participants. A generalized linear mixed (GLM) analysis was adjusted for age, sex, drinking, urinary cotinine, exercise, vitamin intake and body mass index, at a significance level of p<0.05.
Results: A total of 411 participants were finally analyzed after excluding those with diabetes and only one visit to the public health care center. Higher urinary t, t-MA concentrations were linearly associated with the HOMA-IR index, blood insulin level and fasting glucose level in the simple and fully adjusted GLM models. Although there were few limitations, a portion of insulin resistance was proven to be explained by exposure to benzene using r-squared. A significant relationship was also observed between urinary t, t-MA and malondialdehyde (MDA) using the same GLM models.
Conclusions: Urinary t, t-MA is related to the development of insulin resistance which is a key factorfor development of diabetes and its complications induced by oxidative stress
Methods: A panel study was performed on the elderly at a public health care center population in the northern area of Seoul between 2008 and 2010. The participants were 560 elderly, over 60 years of age whose urinary t, t-MA and insulin resistance indices had been measured; questionnaires were completed by these participants. A generalized linear mixed (GLM) analysis was adjusted for age, sex, drinking, urinary cotinine, exercise, vitamin intake and body mass index, at a significance level of p<0.05.
Results: A total of 411 participants were finally analyzed after excluding those with diabetes and only one visit to the public health care center. Higher urinary t, t-MA concentrations were linearly associated with the HOMA-IR index, blood insulin level and fasting glucose level in the simple and fully adjusted GLM models. Although there were few limitations, a portion of insulin resistance was proven to be explained by exposure to benzene using r-squared. A significant relationship was also observed between urinary t, t-MA and malondialdehyde (MDA) using the same GLM models.
Conclusions: Urinary t, t-MA is related to the development of insulin resistance which is a key factorfor development of diabetes and its complications induced by oxidative stress
목차
Abstract
서론
연구대상 및 방법
결과
고찰
요약
참고문헌
참고문헌 (38)
참고문헌 신청
1. [학술지(정기간행물)] - Kim S / 2006 / Using urinary biomarkers to elucidate dose-related patterns of human benzene metabolism / Carcinogenesis 27 : 772 ~ 781
2. [학술지(정기간행물)] - Dougherty D / 2008 / Nqo1, Mpo, Cyp2e1, Gstt1 and Gstm1 polymorphisms and biological effects of benzene exposure--a literature review / Toxicol Lett 182 : 7 ~ 17
3. [학술지(정기간행물)] - Rappaport SM / 2010 / Human benzene metabolism following occupational and environmental exposures / Chem Biol Interact 184 : 189 ~ 195
4. [보고서] - National Institute of Environmental Research / 2010 / Report of air quality in Korea 2009 : 86 ~ 88
5. [학술지(정기간행물)] - Weisel CP / 2010 / Benzene exposure: An overview of monitoring methods and their findings / Chem Biol Interact 184 : 58 ~ 66
2. [학술지(정기간행물)] - Dougherty D / 2008 / Nqo1, Mpo, Cyp2e1, Gstt1 and Gstm1 polymorphisms and biological effects of benzene exposure--a literature review / Toxicol Lett 182 : 7 ~ 17
3. [학술지(정기간행물)] - Rappaport SM / 2010 / Human benzene metabolism following occupational and environmental exposures / Chem Biol Interact 184 : 189 ~ 195
4. [보고서] - National Institute of Environmental Research / 2010 / Report of air quality in Korea 2009 : 86 ~ 88
5. [학술지(정기간행물)] - Weisel CP / 2010 / Benzene exposure: An overview of monitoring methods and their findings / Chem Biol Interact 184 : 58 ~ 66
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UCI(KEPA) : I410-ECN-0101-2013-517-001174528