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논문 기본 정보

자료유형
학술저널
저자정보
Eun-Hwa Sohn (Kangwon National University) Seon-A Jang (Kangwon National University) Chul-Hoon Lee (Hanyang University) Ki-Hyo Jang (Kangwon National University) Se-Chan Kang (Semyung University) Hye-Jin Park (Sungkyunkwan University) Suhkneung Pyo (Sungkyunkwan University)
저널정보
고려인삼학회 Journal of Ginseng Research Journal of Ginseng Research Vol.35 No.4
발행연도
2011.12
수록면
479 - 486 (8page)

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초록· 키워드

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Atopic dermatitis (AD) is an allergic, inflammatory skin disease characterized by chronic eczema and mechanical injury to the skin, caused by scratching. Korean red ginseng (RG) has diverse biological activities, but the molecular effects of RG on allergic diseases, like AD, are unclear. The present study was designed to investigate whether RG inhibits l-chloro-2,4-dinitrobenzeue (DNCB)-induced AD in a mouse model. DNCB was applied topically on the dorsal surface of Balb/c mice to induce AD-like skin lesions. We observed the scratching behavior and examined the serum IgE level and interleukin (IL)-4 and IL-l 0 in splenocytes compared with dexamethasone. We also evaluated the DNCB-induced mitogen-activated protein kinases (MAPKs), NF-KB, and Ikaros activities after RG treatment using reverse transcriptase-polymerase chain reaction, Western blotting, and ELISA. Our data showed that the topical application of RG significantly improved the AD-like skin lesions and scratching behavior. RG decreased not only the mRNA expression of IL-4 and lL-1 0, but also the secretion of IL-4 protein and serum IgE in mice. Additionally, RG treatment decreased the DNCS-induced MAPKs activity and subsequent Ikaros translocation irrespective of NF-KB. We suggest that RG may be useful as a therapeutic nutrition for the treatment of AD.

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INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES

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UCI(KEPA) : I410-ECN-0101-2013-524-001212660