지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.12
- 수록면
- 283 - 291 (9page)
이용수
초록· 키워드
오류제보하기
This study was conducted to provide basic data on physiological and hematological characteristics, and organ weights of beagle dogs. A total of 237 beagle dogs were used to determine differences in physiological and hematological parameters, and organ weights depending on sex and age. The respiratory rate of both sexes tended to increase as they grew older and the female heart rate was slightly higher than that of males. Male and female body weights increased rapidly to 33 weeks old followed by a gradual increase to 41-weeks-old. The relative weight of the brain was negatively correlated with body weight, whereas the weight of reproductive organs was positively correlated with body weight. The platelet count of female dogs was slightly higher than that of males. The red blood cell, hemoglobin, and hematocrit of both sexes increased non-significantly with age. In the leukocyte differential count, the neutrophils, and eosinophils of both sexes tended to increase as they grew older, whereas basophils, lymphocytes, and monocytes decreased. In the serum biochemical profiles, alkaline phosphatase was slightly higher in males than females, while the total cholesterol of female dogs at 9-months-old was higher than that of males at the same age. Other biochemical components, including alanine aminotransferase, blood urea nitrogen, creatinine, triglyceride, and total protein increased nonsignificantly with age in both sexes. To conclude, we observe no significant physiological or hematological differences with sex or age, although decreasing and increasing trends were detected with some parameters. These data provide valuable reference indices of the normal physiological and hematological characteristics of beagle dogs, which should prove useful in toxicological and pharmacological studies.
목차
Materials and Methods
Results
Discussion
References
참고문헌 (27)
참고문헌 신청
1. [학술지(정기간행물)] - Steinmetz KL / 2009 / The basics of preclinical drug development for neurodegenerative disease indications / BMC Neurol 9 (1)
2. [학술지(정기간행물)] - Smith D / 2002 / Preclinical safety evaluation using nonrodent species: an industry/ welfare project to minimize dog use / ILAR J 43 : 39 ~ 42
3. [학술지(정기간행물)] - Meunier LD / 2006 / Selection, acclimation, training, and preparation of dogs for the research setting / ILAR J 47 (1) : 326 ~ 347
4. [학술지(정기간행물)] - Smith D / 2005 / Optimising the design of preliminary toxicity studies for pharmaceutical safety testing in the dog / Regul Toxicol Pharmacol 41 (2) : 95 ~ 101
5. [학술지(정기간행물)] - Phillips B / 2004 / An approach to minimise dog use in regulatory toxicology: production of a best practice guide to study design / Altern Lab Anim 32S1 : 447 ~ 451
2. [학술지(정기간행물)] - Smith D / 2002 / Preclinical safety evaluation using nonrodent species: an industry/ welfare project to minimize dog use / ILAR J 43 : 39 ~ 42
3. [학술지(정기간행물)] - Meunier LD / 2006 / Selection, acclimation, training, and preparation of dogs for the research setting / ILAR J 47 (1) : 326 ~ 347
4. [학술지(정기간행물)] - Smith D / 2005 / Optimising the design of preliminary toxicity studies for pharmaceutical safety testing in the dog / Regul Toxicol Pharmacol 41 (2) : 95 ~ 101
5. [학술지(정기간행물)] - Phillips B / 2004 / An approach to minimise dog use in regulatory toxicology: production of a best practice guide to study design / Altern Lab Anim 32S1 : 447 ~ 451
이 논문의 저자 정보
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2013-510-001228106