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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.12
- 수록면
- 293 - 299 (7page)
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Peroxiredoxin I (Prx I) is a member of the peroxiredoxins (Prxs) family, which are antioxidant enzymes that regulate various cellular process via intracellular oxidative signal pathways. In order to investigate the correlation between Prx I and the γ-secretase complex, which causes Alzheimer’s disease (AD), the expression level of Prx I was firstly evaluated in an animal model for AD. NSE/hPen-2 transgenic (Tg) mice, which were used as animal model in this study, showed a high level of Pen-2 expression and accumulation of Aβ-42 peptides in the hippocampus of brain. The expression level of Prx I was significantly higher on the mRNA and protein level in the brain of this model, while not change in Prx VI expression was observed. Furthermore, to verify the effect of Prx I on the γ-secretase components in vitro, the expression level of these components was analyzed in the Prx I transfectants. Of the components of the γ-secretase complex, the expression of PS-2 and Pen-2 was lower in the transfectants overexpressing Prx I compared to the vector transfectants. However, the expression of APP, NCT and APH-1 did not change in Prx I transfectants. Therefore, these results suggested that the expression of Prx I may be induced by the accumulation of Aβ-42 peptides and the overexpression of Prx I in neuroblastoma cells may regulate the expression of γ-secretase components.
목차
Materials and Methods
Results
Discussion
Acknowledgment
References
참고문헌 (18)
참고문헌 신청
1. [학술지(정기간행물)] - Hoidal JR / 2001 / Reactive oxygen species and cell signaling / Am J Respir Cell Mol Biol 25 (6) : 661 ~ 663
2. [학술지(정기간행물)] - Luo Y / 2009 / Production and radioimmunoimaging of novel fully human phage display recombinant antibodies and growth inhibition of lung adenocarcinoma cell line overexpressing Prx I / Cancer Biol Ther 8 (14) : 1369 ~ 1377
3. [학술지(정기간행물)] - Chae HZ / 1999 / Isoforms of mammalian peroxiredoxin that reduce peroxides in presence of thioredoxin / Methods Enzymol 300 : 219 ~ 226
4. [학술지(정기간행물)] - Seo MS / 2000 / Identification of a new type of mammalian peroxiredoxin that forms an intramolecular disulfide as a reaction intermediate / J Biol Chem 275 (27) : 20346 ~ 20354
5. [학술지(정기간행물)] - Kang SW / 1998 / Mammalian peroxiredoxin isoforms can reduce hydrogen peroxide generated in response to growth factors and tumor necrosis factor-α / J Biol Chem 273 (11) : 6297 ~ 6302
2. [학술지(정기간행물)] - Luo Y / 2009 / Production and radioimmunoimaging of novel fully human phage display recombinant antibodies and growth inhibition of lung adenocarcinoma cell line overexpressing Prx I / Cancer Biol Ther 8 (14) : 1369 ~ 1377
3. [학술지(정기간행물)] - Chae HZ / 1999 / Isoforms of mammalian peroxiredoxin that reduce peroxides in presence of thioredoxin / Methods Enzymol 300 : 219 ~ 226
4. [학술지(정기간행물)] - Seo MS / 2000 / Identification of a new type of mammalian peroxiredoxin that forms an intramolecular disulfide as a reaction intermediate / J Biol Chem 275 (27) : 20346 ~ 20354
5. [학술지(정기간행물)] - Kang SW / 1998 / Mammalian peroxiredoxin isoforms can reduce hydrogen peroxide generated in response to growth factors and tumor necrosis factor-α / J Biol Chem 273 (11) : 6297 ~ 6302
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UCI(KEPA) : I410-ECN-0101-2013-510-001228111