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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.12
- 수록면
- 333 - 338 (6page)
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The cancer stem cell (CSC) hypothesis proposes that CSCs are the root of cancer. CSC-targeted therapies may prevent cancer relapse and provide more effective treatment. The expression of aldehyde dehydrogenase 1, as assessed by the Aldefluor assay, has been recognized as a marker of CSCs in breast cancer. Inhibitors of DNA-binding proteins (IDs) have an important role in stem cell differentiation. In this study, we examined IDs necessary for the regulation of stem properties in Aldefluor<SUP>pos</SUP> 4T1 cells. When the expression profile of IDs in Aldefluor<SUP>neg</SUP> and Aldefluorpos 4T1 cells was compared, qRT-PCR analysis showed that ID4 expression was highly upregulated in Aldefluor<SUB>pos</SUB> 4T1 cells. In addition, knockdown of ID4 expression suppressed the properties of CSCs, including their sphere-forming ability and side population phenotype. The findings suggest that ID4 may be a therapeutic target for the treatment of advanced breast cancer.
목차
Materials and Methods
Results
Discussion
Acknowledgment
References
참고문헌 (26)
참고문헌 신청
Dean M / 2005 / Tumour stem cells and drug resistance / Nat Rev Cancer 5:275~284
Charafe-Jauffret E / 2008 / Cancer stem cells in breast: current opinion and future challenges / Pathobiology 75:75~84
Gangemi R / 2009 / Cancer stem cells: a new paradigm for understanding tumor growth and progression and drug resistance / Curr Med Chem 16:1688~1703
Ginestier C / 2007 / ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome / Cell Stem Cell 1:555~567
Morimoto K / 2009 / Stem cell marker aldehyde dehydrogenase 1-positive breast cancers are characterized by negative estrogen receptor, positive human epidermal growth factor receptor type 2, and high Ki67 expression / Cancer Sci 100:1062~1068
Charafe-Jauffret E / 2008 / Cancer stem cells in breast: current opinion and future challenges / Pathobiology 75:75~84
Gangemi R / 2009 / Cancer stem cells: a new paradigm for understanding tumor growth and progression and drug resistance / Curr Med Chem 16:1688~1703
Ginestier C / 2007 / ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome / Cell Stem Cell 1:555~567
Morimoto K / 2009 / Stem cell marker aldehyde dehydrogenase 1-positive breast cancers are characterized by negative estrogen receptor, positive human epidermal growth factor receptor type 2, and high Ki67 expression / Cancer Sci 100:1062~1068
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UCI(KEPA) : I410-ECN-0101-2013-510-001228166