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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.12
- 수록면
- 365 - 368 (4page)
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Antioxidative and aldose reductase (AR)-inhibitory effects of a fermentation filtrate of Rubus coreanus (FRC) were investigated using corneal/retinal homogenate and lens cytosol, respectively. Rat corneal/retinal homogenate was treated with 50 μM FeCl3 in the presence of FRC (3.2-100 ㎍/mL) for 30 min at 37℃, and thiobarbituric acid-reactive substances (TBARS) was quantified as a lipid peroxidation parameter. FRC markedly suppressed the TBARS production in a concentration-dependent manner, leading to 50% (IC<SUB>50</SUB>) and 100% (IC<SUB>100</SUB>) inhibitory concentrations of 20 and 95 ㎍/mL, respectively, which was similar to the effect of butylated hydroxyanisole. Activity of AR from rat lens was assayed in the presence of FRC (1-31.6 ㎍/mL) at 25℃ using glyceraldehyde as a substrate. FRC inhibited lens AR by 50% (IC<SUB>50</SUB>) and 90% (IC<SUB>90</SUB>) at approximately 2 and 31.6 μg/mL, respectively, comparable to the effect of quercetin. The results indicate that ERC could be a promising candidate for the improvement of eye injury and visual dysfunction of dry eye and diabetic patients.
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UCI(KEPA) : I410-ECN-0101-2013-510-001228237