지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 86 - 92 (7page)
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초록· 키워드
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The glioblastoma multiforme (GBM) is the most common malignant brain tumor in adults. Despite combination treatments of radiation and chemotherapy, the survival periods are very short. Therefore, this study was conducted to assess the potential of ginsenoside F₂ (F2) to treat GBM. In in vitro experiments with glioblastoma cells U373MG, F2 showed the cytotoxic effect with IC?? of 50 ㎍/mL through apoptosis, confi rmed by DNA condensation and fragmentation. The cell population of cell cycle sub-G1 as indicative of apoptosis was also increased. In xenograft model in SD rats, F2 at dosage of 35 ㎎/㎏ weight was intravenously injected every two days. This reduced the tumor growth in magnetic resonance imaging images. The immunohistochemistry revealed that the anticancer activity might be mediated through inhibition of proliferation judged by Ki67 and apoptosis induced by activation of caspase-3 and -8. And the lowered expression of CD31 showed the reduction in blood vessel densities. The expression of matrix metalloproteinase-9 for invasion of cancer was also inhibited. The cell populations with cancer stem cell markers of CD133 and nestin were reduced. The results of this study suggested that F2 could be a new potential chemotherapeutic drug for GBM treatment by inhibiting the growth and invasion of cancer.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
ACKNOWLEDGEMENTS
REFERENCES
참고문헌 (17)
참고문헌 신청
Wen PY. / 2008 / Malignant gliomas in adults / N Engl J Med 359:492~507
Claes A. / 2007 / Diffuse glioma growth : a guerilla war / Acta Neuropathol 114:443~458
Lefranc F. / 2005 / Possible future issues in the treatment of glioblastomas : special emphasis on cell migration and the resistance of migrating glioblastoma cells to apoptosis / J Clin Oncol 23:2411~2422
Cheng L. / 2010 / Potential therapeutic implica tions of cancer stem cells in glioblastoma / Biochem Pharmacol 80:654~665
Hasegawa H. / 1996 / Main ginseng saponin metabolites formed by intestinal bacteria / Planta Med 62:453~457
Claes A. / 2007 / Diffuse glioma growth : a guerilla war / Acta Neuropathol 114:443~458
Lefranc F. / 2005 / Possible future issues in the treatment of glioblastomas : special emphasis on cell migration and the resistance of migrating glioblastoma cells to apoptosis / J Clin Oncol 23:2411~2422
Cheng L. / 2010 / Potential therapeutic implica tions of cancer stem cells in glioblastoma / Biochem Pharmacol 80:654~665
Hasegawa H. / 1996 / Main ginseng saponin metabolites formed by intestinal bacteria / Planta Med 62:453~457
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UCI(KEPA) : I410-ECN-0101-2013-524-001261183